論文 - 詳細
| RRC ID | 51897 |
|---|---|
| 著者 | Poulose AC, Veeranarayanan S, Mohamed MS, Aburto RR, Mitcham T, Bouchard RR, Ajayan PM, Sakamoto Y, Maekawa T, Kumar DS. |
| タイトル | Multifunctional Cu2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453. |
| ジャーナル | Sci Rep |
| Abstract |
Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu2-XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies. |
| 巻・号 | 6 |
| ページ | 35961 |
| 公開日 | 2016-10-24 |
| DOI | 10.1038/srep35961 |
| PII | srep35961 |
| PMID | 27775048 |
| PMC | PMC5075932 |
| MeSH | Antineoplastic Agents / administration & dosage* Breast Neoplasms / drug therapy* Cell Line, Tumor Contrast Media / administration & dosage Copper / administration & dosage Drug Carriers / administration & dosage* Drug Resistance, Multiple* Drug Therapy, Combination / methods* Female Humans Hyperthermia, Induced / methods Models, Biological Nanostructures / administration & dosage* Photoacoustic Techniques Photochemotherapy / methods Photosensitizing Agents Tellurium / administration & dosage Theranostic Nanomedicine X-Rays |
| IF | 3.998 |
| 引用数 | 17 |
| リソース情報 | |
| ヒト・動物細胞 | MDA-MB-453(RCB1192) MCF7(RCB1904) |