RRC ID 51967
Author Santander-Borrego M, Taran E, Shadforth AM, Whittaker AK, Chirila TV, Blakey I.
Title Hydrogels with Lotus Leaf Topography: Investigating Surface Properties and Cell Adhesion.
Journal Langmuir
Abstract The interactions of cells with the surface of materials is known to be influenced by a range of factors that include chemistry and roughness; however, it is often difficult to probe these factors individually without also changing the others. Here we investigate the role of roughness on cell adhesion while maintaining the same underlying chemistry. This was achieved by using a polymerization in mold technique to prepare poly(hydroxymethyl methacrylate) hydrogels with either a flat topography or a topography that replicated the microscale features of lotus leaves. These materials were then assessed for cell adhesion, and atomic force microscopy and contact angle analysis were then used to probe the physical reasons for the differing behavior in relation to cell adhesion.
Volume 33(2)
Pages 485-493
Published 2017-1-17
DOI 10.1021/acs.langmuir.6b03547
PMID 28054787
MeSH Animals Cell Adhesion / drug effects Humans Hydrogels / chemistry* Hydrogels / pharmacology Lotus / anatomy & histology* Microscopy, Atomic Force Plant Leaves / anatomy & histology* Polyhydroxyethyl Methacrylate / chemistry Polyhydroxyethyl Methacrylate / pharmacology
IF 3.789
Human and Animal Cells HCE-T(RCB2280)