| RRC ID |
51981
|
| Author |
Arahira T, Maruta M, Matsuya S.
|
| Title |
Characterization and in vitro evaluation of biphasic α-tricalcium phosphate/β-tricalcium phosphate cement.
|
| Journal |
Mater Sci Eng C Mater Biol Appl
|
| Abstract |
Biphasic calcium phosphate consisting of hydroxyapatite (HA) and β-tricalcium phosphate(β-TCP) is an excellent bone substitute with controllable bioresorbability. Fabrication of biphasic calcium phosphate with self-setting ability is expected to enhance its potential application as bone substitute. In this study, mixtures of α-TCP and β-TCP with various compositions were prepared through α-β phase transition of α-TCP powder at 1000°C for various periods. These powders were mixed with 0.25M Na2HPO4 at a P/L ratio of 2, and then hardened at 37°C at 100% RH for up to 24h. Material properties of biphasic HA/β-TCP cement with different α-TCP/β-TCP composition were characterized. These cements were also evaluated with respect to cell response in vitro using MC3T3-E1 cell lines. In conclusion, mechanical and biological properties of HA/β-TCP cement could be controlled by changing the heat treatment time of α-TCP powder at 1000°C. In vitro results indicated that cell proliferation and ALP activity increased with increase β-TCP content.
|
| Volume |
74
|
| Pages |
478-484
|
| Published |
2017-5-1
|
| DOI |
10.1016/j.msec.2016.12.049
|
| PII |
S0928-4931(16)32605-4
|
| PMID |
28254321
|
| MeSH |
Animals
Bone Substitutes / chemistry*
Bone Substitutes / pharmacology
Calcium Phosphates / chemistry*
Cell Line
Cell Proliferation / drug effects
Hot Temperature
Mice
Microscopy, Electron, Scanning
X-Ray Diffraction
|
| IF |
5.88
|
| Times Cited |
1
|
| Resource |
| Human and Animal Cells |
MC3T3-E1(RCB1126) |
