論文 - 詳細
| RRC ID | 51985 |
|---|---|
| 著者 | Kamei R, Fujimura T, Matsuda M, Kakihara K, Hirakawa N, Baba K, Ono K, Arakawa K, Kawamoto S. |
| タイトル | A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is identified as 8-hydroxy-5,7-dimethoxyflavanone. PDMF significantly inhibits IgE-mediated histamine release from RBL-2H3 rat basophilic leukemia cells as compared with those seen in known P. frutescens-derived anti-inflammatory polyphenols. We also show that oral administration of PDMF not only suppresses passive cutaneous anaphylaxis, but also prevents allergic rhinitis-like nasal symptoms in a murine model of Japanese cedar pollinosis. Mechanistically, PDMF negatively regulates Akt phosphorylation and intracellular Ca2+ influx, both of which are essential for mast cell secretory granule translocation and its exocytosis upon high-affinity IgE receptor (FcεRI) cross-linking. These results represent PDMF as a new potent anti-allergic phytochemical useful for prevention of IgE-driven hypersensitivity reactions. |
| 巻・号 | 483(1) |
| ページ | 674-679 |
| 公開日 | 2017-1-29 |
| DOI | 10.1016/j.bbrc.2016.12.083 |
| PII | S0006-291X(16)32127-1 |
| PMID | 27986566 |
| MeSH | Animals Anti-Allergic Agents / administration & dosage* Anti-Allergic Agents / chemistry Anti-Allergic Agents / isolation & purification Anti-Allergic Agents / pharmacology Cell Line, Tumor Cryptomeria / immunology Disease Models, Animal Drugs, Chinese Herbal / administration & dosage* Drugs, Chinese Herbal / chemistry Drugs, Chinese Herbal / isolation & purification Drugs, Chinese Herbal / pharmacology Female Flavanones / administration & dosage* Flavanones / chemistry Flavanones / isolation & purification Flavanones / pharmacology Histamine Release / drug effects Hypersensitivity, Immediate / prevention & control* Immunoglobulin E / immunology* Mice Mice, Inbred BALB C Passive Cutaneous Anaphylaxis / drug effects Perilla frutescens / chemistry* Plants, Medicinal / chemistry* Rats Receptors, IgE / immunology Rhinitis, Allergic, Seasonal / drug therapy* Rhinitis, Allergic, Seasonal / prevention & control |
| IF | 2.985 |
| 引用数 | 9 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RBL 2H3(RCB2782) |