Reference - Detail
| RRC ID | 52014 |
|---|---|
| Author | Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M. |
| Title | Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces. |
| Journal | Nat Chem Biol |
| Abstract |
Amino-group carrier proteins (AmCPs) mediate the biosynthesis of lysine and arginine in some bacteria and archaea. Here we demonstrate that an uncharacterized AmCP-mediated biosynthetic system functions to biosynthesize the previously uncharacterized and nonproteinogenic amino acid (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH) in Streptomyces sp. SANK 60404. DADH is incorporated into a novel peptide metabolite, vazabitide A, featuring an azabicyclo-ring structure, by nonribosomal peptide synthetases and successive modification enzymes in this bacterium. As the AmCP-mediated machinery for DADH biosynthesis is widely distributed in bacteria, further analysis of uncharacterized AmCP-containing gene clusters will lead to the discovery of novel bioactive compounds and novel biosynthetic enzymes. |
| Volume | 12(11) |
| Pages | 967-972 |
| Published | 2016-11-1 |
| DOI | 10.1038/nchembio.2181 |
| PII | nchembio.2181 |
| PMID | 28288097 |
| MeSH | Arginine / biosynthesis* Arginine / chemistry Carrier Proteins / metabolism* Lysine / biosynthesis* Lysine / chemistry Secondary Metabolism* Streptomyces / metabolism* |
| IF | 12.587 |
| Times Cited | 12 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | PANC-1(RCB2095) |