Reference - Detail
| RRC ID | 52031 |
|---|---|
| Author | Tchoukoua A, Tabopda TK, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Horo I, Çalişkan ÖA, Shiono Y, Ngadjui BT. |
| Title | Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae). |
| Journal | Phytochemistry |
| Abstract |
Seven previously undescribed bidesmosidic triterpenoid saponins named albidosides A - G, were isolated from a methanol extract of the roots of Acacia albida. Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry and determined to be bidesmosides of oleanolic acid and of 16α-hydroxyoleanolic acid. Albidosides B - G were assayed for their cytotoxicity against HeLa and HL60 cells using MTT method and microscopic observation. |
| Volume | 136 |
| Pages | 31-38 |
| Published | 2017-4-1 |
| DOI | 10.1016/j.phytochem.2016.12.019 |
| PII | S0031-9422(16)30304-1 |
| PMID | 28043655 |
| MeSH | Acacia / chemistry* Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Cameroon Drug Screening Assays, Antitumor HL-60 Cells HeLa Cells Humans Inhibitory Concentration 50 Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid / analogs & derivatives* Oleanolic Acid / chemistry Oleanolic Acid / isolation & purification Oleanolic Acid / pharmacology Plant Roots / chemistry Saponins / chemistry Saponins / isolation & purification* |
| IF | 3.044 |
| Times Cited | 8 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) |