| RRC ID |
52035
|
| 著者 |
Sivakumar B, Aswathy RG, Romero-Aburto R, Mitcham T, Mitchel KA, Nagaoka Y, Bouchard RR, Ajayan PM, Maekawa T, Sakthikumar DN.
|
| タイトル |
Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents.
|
| ジャーナル |
Biomater Sci
|
| Abstract |
We have designed versatile polymeric nanoparticles with cancer cell specific targeting capabilities via aptamer conjugation after the successful encapsulation of curcumin and superparamagnetic iron oxide nanoparticles (SPIONs) inside a PLGA nanocapsule. These targeted nanocomposites were selectively taken up by tumor cells, under in vitro conditions, demonstrating the effectiveness of the aptamer targeting mechanism. Moreover, the nanocomposite potentially functioned as efficient multiprobes for optical, magnetic resonance imaging (MRI) and photoacoustic imaging contrast agents in the field of cancer diagnostics. The hyperthermic ability of these nanocomposites was mediated by SPIONs upon NIR-laser irradiation. In vitro cytotoxicity was shown by curcumin-loaded nanoparticles as well as the photothermal ablation of cancer cells mediated by the drug-encapsulated nanocomposite demonstrated the potential therapeutic effect of the nanocomposite. In short, we portray the aptamer-conjugated nanocomposite as a multimodal material capable of serving as a contrast agent for MR, photoacoustic and optical imaging. Furthermore, the nanocomposite functions as a targetable drug nanocarrier and a NIR-laser inducible hyperthermic material that is capable of ablating PANC-1 and MIA PaCa-2 cancer cell lines.
|
| 巻・号 |
5(3)
|
| ページ |
432-443
|
| 公開日 |
2017-2-28
|
| DOI |
10.1039/c6bm00621c
|
| PMID |
28059418
|
| MeSH |
Aptamers, Nucleotide / chemistry*
Cell Line, Tumor
Contrast Media / chemistry*
Drug Carriers / chemistry
Drug Delivery Systems / methods
Humans
Lactic Acid / chemistry*
Magnetic Resonance Imaging / methods
Magnetite Nanoparticles / chemistry*
Multimodal Imaging / methods
Nanocomposites / chemistry*
Neoplasms / diagnostic imaging*
Optical Imaging / methods
Photoacoustic Techniques / methods
Polyglycolic Acid / chemistry*
Polylactic Acid-Polyglycolic Acid Copolymer
|
| IF |
6.183
|
| 引用数 |
24
|
| リソース情報 |
| ヒト・動物細胞 |
PANC-1(RCB2095)
MIA Paca2(RCB2094)
L929 |
