論文 - 詳細
| RRC ID | 52052 |
|---|---|
| 著者 | Motoshima T, Komohara Y, Ma C, Dewi AK, Noguchi H, Yamada S, Nakayama T, Kitada S, Kawano Y, Takahashi W, Sugimoto M, Takeya M, Fujimoto N, Oda Y, Eto M. |
| タイトル | PD-L1 expression in papillary renal cell carcinoma. |
| ジャーナル | BMC Urol |
| Abstract |
BACKGROUND:The immune escape or tolerance of cancer cells is considered to be closely involved in cancer progression. Programmed death-1 (PD-1) is an inhibitory receptor expressed on activating T cells, and several types of cancer cells were found to express PD-1 ligand 1 (PD-L1) and ligand 2 (PD-L2). METHODS:In the present study, we investigated PD-L1/2 expression in papillary renal cell carcinoma (pRCC). RESULT:We found PD-L1 expression in 29 of 102 cases, but no PD-L2 expression was seen. PD-L1 expression was not significantly correlated with any clinicopathological factor, including progression-free survival and overall survival. The frequency of PD-L1-positive cases was higher in type 2 (36%) than in type 1 (22%) pRCC; however, there was no significant difference in the percentages of score 0 cases (p value = 0.084 in Chi-square test). The frequency of high PD-L1 expression cases was higher in type 2 (23%) than in type 1 (11%), and the frequency of high PD-L1 expression cases was higher in grade 3/4 (21%) than in grade 1/2 (13%). However, no significant association was found between PD-L1 expression and all clinicopathological factors in pRCC. CONCLUSION:High expression of PD-L1 in cancer cells was potentially associated to highly histological grade of malignancy in pRCC. The evaluation of the PD-L1 protein might still be useful for predicting the efficacy of anti-cancer immunotherapy using immuno-checkpoint inhibitors, however, not be useful for predicting the clinical prognosis. |
| 巻・号 | 17(1) |
| ページ | 8 |
| 公開日 | 2017-1-13 |
| DOI | 10.1186/s12894-016-0195-x |
| PII | 10.1186/s12894-016-0195-x |
| PMID | 28086852 |
| PMC | PMC5237189 |
| MeSH | Aged B7-H1 Antigen / biosynthesis* Carcinoma, Renal Cell / diagnosis Carcinoma, Renal Cell / metabolism* Female Humans Kidney Neoplasms / diagnosis Kidney Neoplasms / metabolism* Male Retrospective Studies |
| IF | 1.792 |
| 引用数 | 19 |
| リソース情報 | |
| ヒト・動物細胞 | DAUDI(RCB1640) |