Reference - Detail
| RRC ID | 52066 |
|---|---|
| Author | Nguyen NT, Nguyen MT, Nguyen HX, Dang PH, Dibwe DF, Esumi H, Awale S. |
| Title | Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line. |
| Journal | J Nat Prod |
| Abstract |
Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC50 value of 6.6 μg/mL. Phytochemical investigation of this extract led to the isolation of 15 compounds, including eight new cyclohexene chalcones (1-8). The structures of the new compounds were elucidated by NMR spectroscopic data analysis. Among the isolated compounds obtained, isopanduratin A1 (14) and nicolaioidesin C (15) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC50 values of 1.0 and 0.84 μM, respectively. |
| Volume | 80(1) |
| Pages | 141-148 |
| Published | 2017-1-27 |
| DOI | 10.1021/acs.jnatprod.6b00784 |
| PMID | 28099006 |
| MeSH | Antineoplastic Agents, Phytogenic / chemistry Antineoplastic Agents, Phytogenic / isolation & purification* Antineoplastic Agents, Phytogenic / pharmacology Cell Line, Tumor Chalcone / chemistry Chalcone / isolation & purification* Chalcone / pharmacology* Chalcones / chemistry* Chalcones / isolation & purification Chalcones / pharmacology Cyclohexanes / chemistry Cyclohexanes / isolation & purification* Cyclohexanes / pharmacology* Drug Screening Assays, Antitumor Humans Molecular Structure Pancreatic Neoplasms / drug therapy* Plant Extracts / chemistry* Rhizome / chemistry* Zingiberaceae / chemistry* |
| IF | 3.885 |
| Times Cited | 23 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | PANC-1(RCB2095) |