Reference - Detail
| RRC ID | 52081 |
|---|---|
| Author | Kobayashi D, Kakinouchi K, Nagae T, Nagai T, Shimura K, Hazama A. |
| Title | Cesium reversibly suppresses HeLa cell proliferation by inhibiting cellular metabolism. |
| Journal | FEBS Lett |
| Abstract |
The aim of the present study was to investigate the influence of Cs+ on cultured human cells. We find that HeLa cell growth is suppressed by the addition of 10 mm CsCl into the culture media. In the Cs+ -treated cells, the intracellular Cs+ and K+ concentrations are increased and decreased, respectively. This leads to a decrease in activity of the glycolytic enzyme pyruvate kinase, which uses K+ as a cofactor. Cs+ -treated cells show an intracellular pH shift towards alkalization. Based on these results, CsCl presumably suppresses HeLa cell proliferation by inducing an intracellular cation imbalance that affects cell metabolism. Our findings may have implications for the use of Cs+ in cancer therapy. |
| Volume | 591(5) |
| Pages | 718-727 |
| Published | 2017-3-1 |
| DOI | 10.1002/1873-3468.12579 |
| PMID | 28134446 |
| MeSH | Cations, Monovalent Cell Cycle / drug effects* Cell Proliferation / drug effects* Cell Survival / drug effects Cesium / metabolism Cesium / pharmacology* Chlorides / pharmacology* Culture Media / chemistry Glycolysis / drug effects* HeLa Cells Humans Hydrogen-Ion Concentration Potassium / metabolism Pyruvate Kinase / antagonists & inhibitors* Pyruvate Kinase / metabolism |
| IF | 3.057 |
| Times Cited | 3 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HeLa/Fucci(RCB2812) |