論文 - 詳細
| RRC ID | 52089 |
|---|---|
| 著者 | Edeline J, Coulouarn C, Crouzet L, Pracht M, Lepareur N, Clément B, Garin E. |
| タイトル | Gemcitabine and Oxaliplatin, but Not Sorafenib or Paclitaxel, Have a Synergistic Effect with Yttrium-90 in Reducing Hepatocellular Carcinoma and Cholangiocarcinoma Cell Line Viability. |
| ジャーナル | J Vasc Interv Radiol |
| Abstract |
Synergy between yttrium-90 (90Y) and antineoplastic drugs was investigated. Viability of HepaRG (hepatocellular carcinoma) and HuCCT1 (cholangiocarcinoma) cells was studied through a tetrazolium dye reduction assay. A combination index (CI) was calculated, with CI < 1 denoting synergy and CI > 1 denoting antagonism. In HepaRG cells, gemcitabine showed synergy with 90Y (CI = 0.70 [95% confidence interval = 0.65-0.75]), whereas oxaliplatin (CI = 1.15 [1.08-1.21]), paclitaxel (CI = 1.26 [1.15-1.37]), and sorafenib (CI = 1.77 [1.65-1.89]) showed antagonism. In HuCCT1 cells, gemcitabine (CI = 0.54 [0.50-0.58]) and oxaliplatin (CI = 0.86 [0.82-0.90]) showed synergy with 90Y, whereas paclitaxel (CI = 1.18 [1.09-1.27]) and sorafenib (CI = 1.21 [1.12-1.30]) showed antagonism. These results suggest that gemcitabine and oxaliplatin should be tested in combination with 90Y radioembolization for treatment of liver cancer. |
| 巻・号 | 26(12) |
| ページ | 1874-78.e2 |
| 公開日 | 2015-12-1 |
| DOI | 10.1016/j.jvir.2015.06.032 |
| PII | S1051-0443(15)00647-8 |
| PMID | 26596183 |
| MeSH | Antineoplastic Agents / administration & dosage Carcinoma, Hepatocellular / pathology Carcinoma, Hepatocellular / therapy* Cell Line, Tumor Cell Survival / drug effects Cell Survival / radiation effects Chemoradiotherapy / methods Cholangiocarcinoma / pathology Cholangiocarcinoma / therapy* Deoxycytidine / administration & dosage Deoxycytidine / analogs & derivatives* Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug Synergism Gemcitabine Humans Niacinamide / administration & dosage Niacinamide / analogs & derivatives* Organoplatinum Compounds / administration & dosage* Paclitaxel / administration & dosage* Phenylurea Compounds / administration & dosage* Pyridines / administration & dosage* Radiation Tolerance / drug effects Radiopharmaceuticals / administration & dosage Sorafenib Yttrium Radioisotopes / therapeutic use* |
| IF | 2.758 |
| 引用数 | 3 |
| リソース情報 | |
| ヒト・動物細胞 | HuCCT1(RCB1960) |