| RRC ID |
52124
|
| Author |
Zhang J, Hiromoto S, Yamazaki T, Huang H, Jia G, Li H, Yuan G.
|
| Title |
Macrophage phagocytosis of biomedical Mg alloy degradation products prepared by electrochemical method.
|
| Journal |
Mater Sci Eng C Mater Biol Appl
|
| Abstract |
Biomedical Mg alloy is promising for its widespread use clinically. In vitro and in vivo studies showed that the degradation products of biomedical Mg alloy were composed of O, P, Ca, Mg and other alloying elements. However, little is known about the metabolism of the degradation products. In this study, the in vitro macrophage phagocytosis of the degradation products of a biomedical Mg-Nd-Zn-Zr alloy was directly observed. This result affirms the necessity to investigate the long-term fate of Mg alloy degradation products in physiological environments. Besides, an electrochemical method was proposed to prepare enough amount of degradation products in vitro efficiently.
|
| Volume |
75
|
| Pages |
1178-1183
|
| Published |
2017-6-1
|
| DOI |
10.1016/j.msec.2017.02.126
|
| PII |
S0928-4931(16)31266-8
|
| PMID |
28415404
|
| MeSH |
Alloys / chemistry
Alloys / pharmacokinetics
Alloys / pharmacology
Animals
Electrochemical Techniques*
Macrophages / metabolism*
Magnesium* / chemistry
Magnesium* / pharmacokinetics
Magnesium* / pharmacology
Mice
Phagocytosis / drug effects*
RAW 264.7 Cells
|
| IF |
5.88
|
| Times Cited |
8
|
| Resource |
| Human and Animal Cells |
RAW 264(RCB0535) |
