| RRC ID |
52130
|
| Author |
Go S, Go S, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.
|
| Title |
Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.
|
| Journal |
J Biol Chem
|
| Abstract |
Gangliosides (sialic acid-containing glycosphingolipids) help regulate many important biological processes, including cell proliferation, signal transduction, and differentiation, via formation of functional microdomains in plasma membranes. The structural diversity of gangliosides arises from both the ceramide moiety and glycan portion. Recently, differing molecular species of a given ganglioside are suggested to have distinct biological properties and regulate specific and distinct biological events. Elucidation of the function of each molecular species is important and will provide new insights into ganglioside biology. Gangliosides are also suggested to be involved in skeletal muscle differentiation; however, the differential roles of ganglioside molecular species remain unclear. Here we describe striking changes in quantity and quality of gangliosides (particularly GM3) during differentiation of mouse C2C12 myoblast cells and key roles played by distinct GM3 molecular species at each step of the process.
|
| Volume |
292(17)
|
| Pages |
7040-7051
|
| Published |
2017-4-28
|
| DOI |
10.1074/jbc.M116.771253
|
| PII |
S0021-9258(20)42893-5
|
| PMID |
28275055
|
| PMC |
PMC5409471
|
| MeSH |
Animals
Cell Differentiation*
Cell Proliferation
Ceramides / chemistry
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
G(M3) Ganglioside / chemistry*
Glycosphingolipids / chemistry
Lipids / chemistry
Mass Spectrometry
Mice
Myoblasts / cytology*
Myoblasts / metabolism
N-Acetylneuraminic Acid / chemistry
Signal Transduction
|
| IF |
4.238
|
| Times Cited |
7
|
| Resource |
| Human and Animal Cells |
C2C12(RCB0987) |
