論文 - 詳細
| RRC ID | 52143 |
|---|---|
| 著者 | Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T. |
| タイトル | Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas. |
| ジャーナル | Molecules |
| Abstract |
We isolated a new ellagitannin, davicratinic acid A (5), together with four known ellagitannins, davidiin (1), granatin A (2), pedunculagin (3), and 3-O-galloylgranatin A (4), from an aqueous acetone extract of dried Davidia involucrata leaves. The known ellagitannins were identified based on spectroscopic data. The structure of davicratinic acid A (5), a monomeric ellagitannin possessing a unique, skew-boat glucopyranose core, was established based on spectroscopic data. Additionally, we examined the effects of several tannins with good yields from this plant on drug-resistant bacteria and human oral squamous cell carcinomas, and found that davidiin (1) exhibited the most potent antibacterial and antitumor properties among the tannins examined. |
| 巻・号 | 22(3) |
| 公開日 | 2017-3-15 |
| DOI | 10.3390/molecules22030470 |
| PII | molecules22030470 |
| PMID | 28294988 |
| PMC | PMC6155176 |
| MeSH | Carcinoma, Squamous Cell / drug therapy* Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Cornaceae / chemistry* Drug Resistance, Bacterial / drug effects* Drug Screening Assays, Antitumor Humans Hydrolyzable Tannins / chemistry* Hydrolyzable Tannins / pharmacology Molecular Structure Mouth Neoplasms / drug therapy* Plant Extracts / chemistry Plant Extracts / pharmacology |
| IF | 3.267 |
| 引用数 | 10 |
| リソース情報 | |
| ヒト・動物細胞 | Ca9-22(RCB1976) HSC-2(RCB1945) HSC-3(RCB1975) HSC-4(RCB1902) |