| RRC ID |
52156
|
| Author |
Colombe S, Houllier L, Fleurot E, Levallet G, Benhaïm A, Bonnamy PJ, Levallet J.
|
| Title |
Syndecan 1 represses cell growth and FSH responsiveness in human granulosa cells.
|
| Journal |
Reproduction
|
| Abstract |
Additionally, we provide evidence that transient cAMP accumulation reduction in cells overexpressing syndecan 1 is accompanied by an increase in cAMP-hydrolysing PDE activity. Our results demonstrated that syndecan 1 might regulate differentiation of granulosa cells and follicular development by means of various mechanisms involving morphological changes, control of signalling pathways and alterations in gene expressions.Free French abstract: A French translation of this abstract is freely available at http://www.reproduction-online.org/content/153/6/797/suppl/DC1.Reproduction.
|
| Volume |
153(6)
|
| Pages |
797-808
|
| Published |
2017-6
|
| DOI |
10.1530/REP-17-0074
|
| PII |
REP-17-0074
|
| PMID |
28348070
|
| MeSH |
Aromatase / metabolism
Cell Cycle / drug effects
Cell Differentiation / drug effects
Cell Proliferation / drug effects*
Female
Follicle Stimulating Hormone / pharmacology*
Gene Expression Regulation, Neoplastic / drug effects*
Granulosa Cell Tumor / drug therapy
Granulosa Cell Tumor / metabolism
Granulosa Cell Tumor / pathology*
Humans
Middle Aged
Receptors, FSH / metabolism
Signal Transduction
Syndecan-1 / metabolism*
Tumor Cells, Cultured
|
| IF |
3.086
|
| Resource |
| Human and Animal Cells |
KGN(RCB1154) |
