RRC ID 52156
Author Colombe S, Houllier L, Fleurot E, Levallet G, Benhaïm A, Bonnamy PJ, Levallet J.
Title Syndecan 1 represses cell growth and FSH responsiveness in human granulosa cells.
Journal Reproduction
Abstract Additionally, we provide evidence that transient cAMP accumulation reduction in cells overexpressing syndecan 1 is accompanied by an increase in cAMP-hydrolysing PDE activity. Our results demonstrated that syndecan 1 might regulate differentiation of granulosa cells and follicular development by means of various mechanisms involving morphological changes, control of signalling pathways and alterations in gene expressions.Free French abstract: A French translation of this abstract is freely available at http://www.reproduction-online.org/content/153/6/797/suppl/DC1.Reproduction.
Volume 153(6)
Pages 797-808
Published 2017-6
DOI 10.1530/REP-17-0074
PII REP-17-0074
PMID 28348070
MeSH Aromatase / metabolism Cell Cycle / drug effects Cell Differentiation / drug effects Cell Proliferation / drug effects* Female Follicle Stimulating Hormone / pharmacology* Gene Expression Regulation, Neoplastic / drug effects* Granulosa Cell Tumor / drug therapy Granulosa Cell Tumor / metabolism Granulosa Cell Tumor / pathology* Humans Middle Aged Receptors, FSH / metabolism Signal Transduction Syndecan-1 / metabolism* Tumor Cells, Cultured
IF 3.086
Resource
Human and Animal Cells KGN(RCB1154)