Reference - Detail
RRC ID | 52163 |
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Author | Andoh T, Uta D, Kato M, Toume K, Komatsu K, Kuraishi Y. |
Title | Prophylactic Administration of Aucubin Inhibits Paclitaxel-Induced Mechanical Allodynia via the Inhibition of Endoplasmic Reticulum Stress in Peripheral Schwann Cells. |
Journal | Biol Pharm Bull |
Abstract |
Paclitaxel is a chemotherapeutic agent that causes peripheral neuropathy as its major dose-limiting side effect. However, the peripheral neuropathy is difficult to manage. A study we recently conducted showed that repetitive administration of aucubin as a prophylactic inhibits paclitaxel-induced mechanical allodynia. However, the mechanisms underlying the anti-allodynic activity of aucubin, which is a major component of Plantaginis Semen, was unclear. In addition to mechanical allodynia, aucubin inhibited spontaneous and mechanical stimuli-induced firing in spinal dorsal horn neurons; however, catalpol, a metabolite of aucubin, did not show these effects. Furthermore, paclitaxel induced the expression of CCAAT/enhancer-binding protein homologous protein, a marker of endoplasmic reticulum (ER) stress, in the sciatic nerve and a Schwann cell line (LY-PPB6 cells); however, this effect was inhibited by aucubin. These results suggest that aucubin inhibits paclitaxel-induced mechanical allodynia through the inhibition of ER stress in peripheral Schwann cells. |
Volume | 40(4) |
Pages | 473-478 |
Published | 2017-1-1 |
DOI | 10.1248/bpb.b16-00899 |
PMID | 28381802 |
MeSH | Animals Antineoplastic Agents, Phytogenic / toxicity Cell Line Endoplasmic Reticulum Stress / drug effects* Endoplasmic Reticulum Stress / physiology Hyperalgesia / chemically induced Hyperalgesia / metabolism Hyperalgesia / prevention & control* Iridoid Glucosides / administration & dosage* Male Mice Mice, Inbred C57BL Paclitaxel / antagonists & inhibitors Paclitaxel / toxicity* Posterior Horn Cells / drug effects Posterior Horn Cells / metabolism Pre-Exposure Prophylaxis / methods* Rats Schwann Cells / drug effects* Schwann Cells / metabolism |
IF | 1.863 |
Times Cited | 9 |
Resource | |
Human and Animal Cells | LY-PPB6(RCB2729) |