RRC ID 52242
著者 Tu PS, Tung YT, Lee WT, Yen GC.
タイトル Protective Effect of Camellia Oil (Camellia oleifera Abel.) against Ethanol-Induced Acute Oxidative Injury of the Gastric Mucosa in Mice.
ジャーナル J Agric Food Chem
Abstract Camellia oil, a common edible oil in Taiwan and China, has health effects for the gastrointestinal tract in folk medicine, and it contains abundant unsaturated fatty acids and phytochemicals. However, the preventive effect of camellia oil on ethanol-induced gastric ulcers remains unclear. This study was aimed to evaluate the preventive effect of camellia oil on ethanol-induced gastric injury in vitro and in vivo as well as its mechanisms of action. In an in vitro study, our results showed that pretreatment of RGM-1 cells with camellia oil enhanced the migration ability as well as increased heat shock protein expression and reduced apoptotic protein expression. In animal experiments, mice pretreated with camellia oil effectively showed improved ethanol-induced acute injury of the gastric muscosa and oxidative damage through the enhancement of antioxidant enzyme activities and heat shock protein and PGE2 production, as well as the suppression of lipid peroxidation, apoptosis-related proteins, pro-inflammatory cytokines, and NO production. Histological injury score and hemorrhage score in ethanol-induced gastric mucosal damage dramatically elevated from the control group (0.00 ± 0.0) to 3.40 ± 0.7 and 2.60 ± 0.5, respectively. However, treatments with camellia oil or olive oil (2 mL/kg bw) and lansoprazole (30 mg/kg bw) showed significant decreases in elevation of injury score and hemorrhage score (p < 0.05). Therefore, camellia oil has the potential to ameliorate ethanol-induced acute gastric mucosal injury through the inhibition of inflammation and oxidative stress.
巻・号 65(24)
ページ 4932-4941
公開日 2017-6-21
DOI 10.1021/acs.jafc.7b01135
PMID 28562049
MeSH Animals Apoptosis / drug effects Camellia / chemistry* Ethanol / toxicity* Gastric Mucosa / drug effects Gastric Mucosa / injuries Humans Lipid Peroxidation / drug effects Male Mice Mice, Inbred BALB C Oxidative Stress / drug effects Plant Extracts / administration & dosage* Plant Oils / administration & dosage* Stomach Ulcer / chemically induced Stomach Ulcer / drug therapy* Stomach Ulcer / physiopathology
IF 3.571
引用数 25
リソース情報
ヒト・動物細胞 RGM1(RCB0876)