論文 - 詳細
| RRC ID | 52270 |
|---|---|
| 著者 | Takamura T, Suguro H, Mikami Y, Iwase T, Komiyama Y, Kuyama K, Komiyama K, Oki H. |
| タイトル | Comparison of gene expression profiles of gingival carcinoma Ca9-22 cells and colorectal adenocarcinoma HT-29 cells to identify potentially important mediators of SLPI-induced cell migration. |
| ジャーナル | J Oral Sci |
| Abstract |
Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor whose expression level is positively correlated with tumor aggressiveness and metastatic potential. However, the mechanism underlying SLPI-induced enhancement of malignant phenotype is not completely understood. The malignancy of cancer cells is highly dependent on cell migration activity. Our previous study revealed that gingival carcinoma Ca9-22 cells, but not colorectal adenocarcinoma HT-29 cells, expressed SLPI. Therefore, we investigated the migration activity of these two cell types to understand the nature of SLPI-mediated tumor aggressiveness and metastatic potential. In vitro wound healing assay indicated that HT-29 cells and SLPI-deleted Ca9-22 cells showed lower migration activity than wild-type Ca9-22 cells, suggesting that SLPI-induced cell migration plays an important role in tumor aggressiveness and metastatic potential. In addition, our gene expression profiling study based on microarray data for the three cell types identified a number of candidates, including LCP1 and GLI, that could be key molecules in the mechanism of SLPI-induced cell migration. |
| 巻・号 | 59(2) |
| ページ | 279-287 |
| 公開日 | 2017-1-1 |
| DOI | 10.2334/josnusd.16-0534 |
| PMID | 28637988 |
| MeSH | Adenocarcinoma / genetics* Adenocarcinoma / pathology Cell Movement / physiology* Colorectal Neoplasms / genetics* Colorectal Neoplasms / pathology Gene Expression Profiling* Gingival Neoplasms / genetics* Gingival Neoplasms / pathology HT29 Cells Humans Neoplasm Metastasis Secretory Leukocyte Peptidase Inhibitor / genetics Secretory Leukocyte Peptidase Inhibitor / physiology* |
| IF | 1.2 |
| 引用数 | 0 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Ca9-22(RCB1976) |