Reference - Detail
| RRC ID | 52317 |
|---|---|
| Author | Rodriguez R, Yoshimura K, Shibata Y, Miyamoto Y, Tanaka R, Uyama R, Sasa K, Suzuki D, Miyazaki T, Kamijo R. |
| Title | Nanoindentation time-dependent deformation/recovery suggestive of methylglyoxal induced glycation in calcified nodules. |
| Journal | Nanomedicine |
| Abstract |
Although empirical findings have indicated increase in bone fracture risk in type 2 diabetes patients, that has yet to be proven by results obtained at the material level. Here, we report evidence showing nanoscale time-dependent deformation/recovery of in vitro calcified nodules mimicking bone turnover in type 2 diabetes in respect to methylglyoxal (MG)-induced glycation. Nanoindentation test results revealed that calcified nodules cultured with MG did not show adequate dimensional recovery, despite a large creep rate during constant load indentation testing. This lesser recovery is likely based on the linear matrix polymerization network formed by advanced glycation end products (AGEs) as a secondary product of MG. Since elevated serum MG and abnormal bone turnover related to the amount of AGEs are observed in cases of type 2 diabetes, this time-dependent behavior may be one of the factors of the bone fracture mechanism at the material level in affected patients. |
| Volume | 13(8) |
| Pages | 2545-2553 |
| Published | 2017-11-1 |
| DOI | 10.1016/j.nano.2017.07.003 |
| PII | S1549-9634(17)30133-8 |
| PMID | 28754466 |
| MeSH | Bone and Bones / metabolism Bone and Bones / pathology Calcinosis / metabolism* Calcinosis / pathology Cell Line Cell Proliferation Diabetes Mellitus, Type 2 / metabolism* Diabetes Mellitus, Type 2 / pathology Glycation End Products, Advanced / metabolism* Humans Osteoblasts / cytology Osteoblasts / metabolism* Osteoblasts / pathology Pyruvaldehyde / metabolism* |
| IF | 4.3 |
| Times Cited | 2 |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |