論文 - 詳細
| RRC ID | 52475 |
|---|---|
| 著者 | Hayashi K, Yamada S, Hayashi H, Sakamoto W, Yogo T. |
| タイトル | Red blood cell-like particles with the ability to avoid lung and spleen accumulation for the treatment of liver fibrosis. |
| ジャーナル | Biomaterials |
| Abstract |
Micro-sized drug-carrier particles accumulate mainly in the lungs and nano-sized particles tend to accumulate in the liver and spleen. Here, we show that micro-particles designed to mimic red blood cells (RBCs) can overcome these limitations. The RBC-MPs created in this study have a unique intra-particle elasticity distribution (IED), enabling them to bend around the central axis of the RBC-like dent, enabling them to pass through pores smaller than their diameter, mechanically behaving as authentic RBCs. In contrast, spherical MPs (SPH-MPs) and RBC-MPs hardened by incorporating a siloxane network (SiO2-RBC-MPs), could not. In addition to the IED, we discovered that the deformability also depends on the shape and average particle elasticity. RBC-MPs did not accumulate in the lungs and the spleen, but were targeted specifically to the liver instead. In contrast, non-RBC-MPs such as SPH-MPs and SiO2-RBC-MPs showed heavy accumulation in the lungs and/or spleen, and were dispersed non-specifically in various organs. Thus, controlling the shape and mechanical properties of RBC-MPs is important for achieving the desired biodistribution. When RBC-MPs were loaded with a (TGF)-β receptor inhibitor, RBC-MPs could treat liver fibrosis without pneumotoxicity. |
| 巻・号 | 156 |
| ページ | 45-55 |
| 公開日 | 2018-2-1 |
| DOI | 10.1016/j.biomaterials.2017.11.031 |
| PII | S0142-9612(17)30760-3 |
| PMID | 29190497 |
| MeSH | Animals Elasticity Erythrocytes / metabolism* Female Fluorescence Liver / pathology Liver Cirrhosis / pathology Liver Cirrhosis / therapy* Lung / metabolism* Male Mice, Inbred C57BL Microspheres* Particle Size Porosity Spleen / metabolism* Tissue Distribution |
| IF | 10.317 |
| 引用数 | 8 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | KUP5(RCB4627) |