RRC ID 52503
Author Fujimaki T, Mori S, Horikawa M, Fukui Y.
Title Isolation of proanthocyanidins from red wine, and their inhibitory effects on melanin synthesis in vitro.
Journal Food Chem
Abstract The red wines made from Vitis vinifera were identified as skin-whitening effectors by using in vitro assays. OPCs in the wine were evaluated for tyrosinase activity and melanogenesis. Strong tyrosinase inhibitory activity was observed in fractions with high oligomeric proanthocyanidin (OPC) content. Among OPC dimers, a strong inhibitory effect on tyrosinase was observed with OPCs which contain (+)-catechin as an upper unit. Melanogenesis inhibitory effect was observed with OPCs which have (-)-epicatechin as upper units. Also, OPC trimers, upper and middle units joined with 4 → 8 bonds, showed stronger effects compared to trimers with 4 → 6 linkages. Interestingly, (-)-epicatechin-(4β → 8)-(-)-epicatechin 3-O-gallate, which is a unique component of grapes has potent inhibitory effects on both tyrosinase and melanogenesis. Our data provide structural information about such active compounds. These results suggest that red wines containing OPC, have high melanogenesis inhibitory effect and are supposed to have skin-whitening effect.
Volume 248
Pages 61-69
Published 2018-5-15
DOI 10.1016/j.foodchem.2017.12.024
PII S0308-8146(17)31963-5
PMID 29329871
MeSH Animals Catechin / analogs & derivatives Catechin / isolation & purification Catechin / pharmacology Cell Line, Tumor Drug Evaluation, Preclinical / methods Enzyme Inhibitors / pharmacology Melanins / antagonists & inhibitors* Melanins / biosynthesis Melanoma / drug therapy Melanoma / metabolism Melanoma / pathology Mice Monophenol Monooxygenase / antagonists & inhibitors Proanthocyanidins / analysis Proanthocyanidins / isolation & purification* Proanthocyanidins / pharmacology* Vitis / chemistry* Wine* / analysis
IF 6.306
Times Cited 9
Human and Animal Cells B16 melanoma(RCB1283)