Reference - Detail
| RRC ID | 52530 |
|---|---|
| Author | Manse Y, Ninomiya K, Nishi R, Hashimoto Y, Chaipech S, Muraoka O, Morikawa T. |
| Title | Labdane-Type Diterpenes, Galangalditerpenes A-C, with Melanogenesis Inhibitory Activity from the Fruit of Alpinia galanga. |
| Journal | Molecules |
| Abstract |
In our continuing study of biologically active natural products from the fruit of Alpinia galanga (Zingiberaceae), we newly isolated three new labdane-type diterpenes, termed galangalditerpenes A-C (1-3), along with four known sesquiterpenes (4-7) and two diterpenes (8 and 9). The stereostructures of 1-3 were elucidated on the basis of their spectroscopic properties. The melanogenesis inhibitory activities in theophylline-stimulated murine B16 melanoma 4A5 cells of these isolates, including the new diterpenes (1-3, IC50 = 4.4, 8.6, and 4.6 μM, respectively), were found to be more than 6-87-fold higher than that of arbutin (174 μM), a commercially available positive control. |
| Volume | 22(12) |
| Published | 2017-12-20 |
| DOI | 10.3390/molecules22122279 |
| PII | molecules22122279 |
| PMID | 29261124 |
| PMC | PMC6149739 |
| MeSH | Alpinia / chemistry* Animals Arbutin / chemistry Arbutin / pharmacology Cell Line, Tumor Cell Survival / drug effects Diterpenes / chemistry* Diterpenes / isolation & purification Diterpenes / pharmacology Fruit / chemistry* Melanins / metabolism* Melanoma, Experimental Mice Molecular Conformation Plant Extracts / chemistry Plant Extracts / isolation & purification Plant Extracts / pharmacology Sesquiterpenes / chemistry Sesquiterpenes / isolation & purification Sesquiterpenes / pharmacology Structure-Activity Relationship |
| IF | 3.267 |
| Times Cited | 6 |
| Resource | |
| Human and Animal Cells | B16 melanoma 4A5(RCB0557) |