| RRC ID |
52599
|
| Author |
Takahashi J, Murakami M, Mori T, Iwahashi H.
|
| Title |
Verification of radiodynamic therapy by medical linear accelerator using a mouse melanoma tumor model.
|
| Journal |
Sci Rep
|
| Abstract |
Combined treatment with 5-aminolevulinic acid (5-ALA) and X-rays improves tumor suppression in vivo. This is because the accumulated protoporphyrin IX from 5-ALA enhances the generation of ROS by the X-ray irradiation. In the present study, a high-energy medical linear accelerator was used instead of a non-medical low energy X-ray irradiator, which had been previously used. Tumor-bearing mice implanted with B16-BL6 melanoma cells were treated with fractionated doses of irradiation (in total, 20 or 30 Gy), using two types of X-ray irradiator after 5-ALA administration. Suppression of tumor growth was enhanced with X-ray irradiation in combination with 5-ALA treatment compared with X-ray treatment alone, using both medical and non-medical X-ray irradiators. 5-ALA has been used clinically for photodynamic therapy. Thus, "radiodynamic therapy", using radiation from medical linacs as a physical driving force, rather than the light used in photodynamic therapy, may have potential clinical applications.
|
| Volume |
8(1)
|
| Pages |
2728
|
| Published |
2018-2-9
|
| DOI |
10.1038/s41598-018-21152-z
|
| PII |
10.1038/s41598-018-21152-z
|
| PMID |
29426920
|
| PMC |
PMC5807383
|
| MeSH |
Aminolevulinic Acid / pharmacology*
Animals
Melanoma, Experimental / metabolism
Melanoma, Experimental / pathology
Melanoma, Experimental / therapy*
Mice
Mice, Inbred C57BL
Particle Accelerators / instrumentation*
Photochemotherapy / methods*
Photosensitizing Agents / pharmacology*
Protoporphyrins / metabolism
Reactive Oxygen Species / metabolism*
Tumor Cells, Cultured
X-Rays
|
| IF |
3.998
|
| Times Cited |
11
|
| Resource |
| Human and Animal Cells |
B16/BL6(RCB2638) |
