| RRC ID |
52684
|
| 著者 |
Hatai M, Yoshikawa N, Kinoshita E, Horiyama S, Kagota S, Shinozuka K, Nakamura K.
|
| タイトル |
Invasion-inhibiting Effects of Gaseous Components in Cigarette Smoke on Mouse Rectal Carcinoma Colon-26 Cells.
|
| ジャーナル |
In Vivo
|
| Abstract |
We investigated the anti-metastatic action of nicotine- and tar-removed cigarette smoke extract (CSE) on highly metastatic mouse Colon-26 cells using syngeneic BALB/c mice. Colon-26 cells were injected into the spleen of mice, cells were grown in the spleen as the primary lesion, and some metastasized from the spleen to liver and established a metastatic lesion. CSE (10, 30, and 100%) was intraperitoneally administered daily to the mice for 14 days after tumor inoculation. As a result, the relative spleen weights of CSE-administered mice did not differ significantly from those of the control mice. However, the relative liver weights of CSE 30%-administered mice significantly decreased compared to control mice. In order to identify the active component in CSE, we examined the action of methyl vinyl ketone (MVK) on the invasiveness of Colon-26 cells. MVK significantly reduced the invasiveness of cells. MVK may be a candidate active component of CSE.
|
| 巻・号 |
32(3)
|
| ページ |
493-497
|
| 公開日 |
2018-1-1
|
| DOI |
10.21873/invivo.11266
|
| PII |
32/3/493
|
| PMID |
29695551
|
| PMC |
PMC6000804
|
| MeSH |
Animals
Butanones / pharmacology
Cell Line, Tumor
Cell Movement / drug effects
Cell Proliferation / drug effects
Cell Survival / drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Mice
Nicotine / pharmacology
Rectal Neoplasms
Smoke / adverse effects*
Smoking*
Tars / chemistry*
Tars / pharmacology*
|
| IF |
1.541
|
| 引用数 |
1
|
| リソース情報 |
| ヒト・動物細胞 |
Colon-26(RCB2657) |
