RRC ID 52716
著者 Tazawa I, Yaoita Y.
タイトル Vitamin A induced homeotic hindlimb formation on dorsal and ventral sides of regenerating tissue of amputated tails of Japanese brown frog tadpoles.
ジャーナル Dev Growth Differ
Abstract When anuran tadpoles are treated with vitamin A after tail amputation, hindlimb-like structures can be generated instead of the lost tail part at the amputation site. This homeotic transformation was initially expected to be a key to understanding the body plan of vertebrates. Unfortunately, homeotic limb formation has been reproduced in only some Indian frog species and a European species, but not in experimental anurans such as Xenopus laevis or Rana catesbeiana. Consequently, this fascinating phenomenon has not been well analyzed, especially at the molecular level. In addition, the initial processes of ectopic limb development are also unclear because morphological changes in the early phases have not been analyzed in detail. In this study, we report the induction of homeotic transformation using Japanese brown frogs and present a detailed morphological analysis. Unexpectedly, the ectopic limbs developed not only at the ventral sites, but also at the dorsal sites of the tail regenerates of vitamin A-treated tadpoles. The relationship between position and axial orientation of ectopic limbs suggested the double duplication of positional value order along the rostral-caudal axis and the dorsal-ventral axis of the tail regenerates.
巻・号 59(9)
ページ 688-700
公開日 2017-12-1
DOI 10.1111/dgd.12407
PMID 29094344
MeSH Amputation, Surgical Animals Extremities / embryology Hindlimb / drug effects* Larva / drug effects Regeneration / drug effects Vitamin A / therapeutic use* Wound Healing / drug effects
IF 1.723
引用数 3
リソース情報
ツメガエル・イモリ Xenopus tropicalis