RRC ID 52797
Author Muraosa Y, Oguchi M, Yahiro M, Watanabe A, Yaguchi T, Kamei K.
Title Epidemiological Study of Fusarium Species Causing Invasive and Superficial Fusariosis in Japan.
Journal Med Mycol J
Abstract In Japan, Fusarium species are known etiological agents of human fungal infection; however, there has been no report of a large-scale epidemiological study on the etiological agents of fusariosis. A total of 73 Fusarium isolates from patients with invasive fusariosis (IF, n= 36) or superficial fusariosis (SF, n= 37), which were obtained at hospitals located in 28 prefectures in Japan between 1998 and 2015, were used for this study. Fusarium isolates were identified using Fusarium- and Fusarium solani species complex (FSSC) -specific real-time PCR and partial DNA sequences of the elongation factor-1 alpha (EF-1α) gene and the nuclear ribosomal internal transcribed spacer (ITS) region. FSSC was predominately isolated from both patients with IF and SF (IF, 77.8% and SF, 67.6%). Distribution of the phylogenetic species of FSSC isolates from patients with IF and SF exhibited different spectra; specifically, F. keratoplasticum (FSSC 2) (25.0%) was the most frequent isolate from patients with IF, whereas F. falciforme (FSSC 3+4) (32.4%) was the most frequent isolate from patients with SF. Fusarium sp. (FSSC 5) was the second most frequent isolate from both patients with IF and SF (IF, 22.2% and SF, 24.3%). Notably, F. petroliphilum (FSSC 1) was isolated only from patients with IF. Each species was isolated from a broad geographic area, and an epidemic was not observed. This is the first epidemiological study of Fusarium species causing IF and SF in Japan.
Volume 58(1)
Pages E5-E13
Published 2017-2-28
DOI 10.3314/mmj.16-00024
PMID 28250364
MeSH Animals Fusariosis / epidemiology* Fusariosis / microbiology* Fusarium / classification Fusarium / isolation & purification* Fusarium / pathogenicity* Humans Japan / epidemiology
Pathogenic eukaryotic microorganisms 病原真菌:IFM 49277, IFM 58043, IFM 59380, IFM 61165, IFM 61380, IFM 49272, IFM 49274, IFM 50956, IFM 58015, IFM 59778, IFM 62236, IFM 62550, IFM 62701, IFM 63624 他計73株