RRC ID |
52797
|
著者 |
Muraosa Y, Oguchi M, Yahiro M, Watanabe A, Yaguchi T, Kamei K.
|
タイトル |
Epidemiological Study of Fusarium Species Causing Invasive and Superficial Fusariosis in Japan.
|
ジャーナル |
Med Mycol J
|
Abstract |
In Japan, Fusarium species are known etiological agents of human fungal infection; however, there has been no report of a large-scale epidemiological study on the etiological agents of fusariosis. A total of 73 Fusarium isolates from patients with invasive fusariosis (IF, n= 36) or superficial fusariosis (SF, n= 37), which were obtained at hospitals located in 28 prefectures in Japan between 1998 and 2015, were used for this study. Fusarium isolates were identified using Fusarium- and Fusarium solani species complex (FSSC) -specific real-time PCR and partial DNA sequences of the elongation factor-1 alpha (EF-1α) gene and the nuclear ribosomal internal transcribed spacer (ITS) region. FSSC was predominately isolated from both patients with IF and SF (IF, 77.8% and SF, 67.6%). Distribution of the phylogenetic species of FSSC isolates from patients with IF and SF exhibited different spectra; specifically, F. keratoplasticum (FSSC 2) (25.0%) was the most frequent isolate from patients with IF, whereas F. falciforme (FSSC 3+4) (32.4%) was the most frequent isolate from patients with SF. Fusarium sp. (FSSC 5) was the second most frequent isolate from both patients with IF and SF (IF, 22.2% and SF, 24.3%). Notably, F. petroliphilum (FSSC 1) was isolated only from patients with IF. Each species was isolated from a broad geographic area, and an epidemic was not observed. This is the first epidemiological study of Fusarium species causing IF and SF in Japan.
|
巻・号 |
58(1)
|
ページ |
E5-E13
|
公開日 |
2017-2-28
|
DOI |
10.3314/mmj.16-00024
|
PMID |
28250364
|
MeSH |
Animals
Fusariosis / epidemiology*
Fusariosis / microbiology*
Fusarium / classification
Fusarium / isolation & purification*
Fusarium / pathogenicity*
Humans
Japan / epidemiology
|
リソース情報 |
病原真核微生物 |
病原真菌:IFM 49277, IFM 58043, IFM 59380, IFM 61165, IFM 61380, IFM 49272, IFM 49274, IFM 50956, IFM 58015, IFM 59778, IFM 62236, IFM 62550, IFM 62701, IFM 63624 他計73株 |