| RRC ID |
5308
|
| Author |
Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A.
|
| Title |
Autophagy-dependent viral recognition by plasmacytoid dendritic cells.
|
| Journal |
Science
|
| Abstract |
Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-alpha by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.
|
| Volume |
315(5817)
|
| Pages |
1398-401
|
| Published |
2007-3-9
|
| DOI |
10.1126/science.1136880
|
| PII |
1136880
|
| PMID |
17272685
|
| MeSH |
Animals
Autophagy*
Dendritic Cells / immunology*
Dendritic Cells / physiology
Dendritic Cells / virology*
Endosomes / immunology
Endosomes / virology
Female
Immunity, Innate
Interferon-alpha / metabolism
Interleukin-12 / metabolism
Lysosomes / virology
Male
Membrane Glycoproteins / immunology*
Mice
Mice, Transgenic
Phagosomes / physiology
Phagosomes / ultrastructure
RNA, Viral / immunology*
RNA, Viral / metabolism
Rhabdoviridae Infections / immunology*
Toll-Like Receptor 7 / immunology*
Vesicular stomatitis Indiana virus / immunology*
Vesicular stomatitis Indiana virus / physiology
Virus Replication
|
| IF |
41.846
|
| Times Cited |
633
|
|
WOS Category
|
IMMUNOLOGY
|
| Resource |
| Mice |
RBRC00806 |
