RRC ID 53095
Author Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC.
Title Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis.
Journal Elife
Abstract Many multicellular organisms rely on symbiotic associations for support of metabolic activity, protection, or energy. Understanding the mechanisms involved in controlling such interactions remains a major challenge. In an unbiased approach we identified key players that control the symbiosis between Hydra viridissima and its photosynthetic symbiont Chlorella sp. A99. We discovered significant up-regulation of Hydra genes encoding a phosphate transporter and glutamine synthetase suggesting regulated nutrition supply between host and symbionts. Interestingly, supplementing the medium with glutamine temporarily supports in vitro growth of the otherwise obligate symbiotic Chlorella, indicating loss of autonomy and dependence on the host. Genome sequencing of Chlorella sp. A99 revealed a large number of amino acid transporters and a degenerated nitrate assimilation pathway, presumably as consequence of the adaptation to the host environment. Our observations portray ancient symbiotic interactions as a codependent partnership in which exchange of nutrients appears to be the primary driving force.
Volume 7
Published 2018-5-31
DOI 10.7554/eLife.35122
PII 35122
PMID 29848439
PMC PMC6019070
MeSH Animals Biological Evolution* Chlorella / drug effects Chlorella / genetics Chlorella / metabolism* Conserved Sequence Darkness Epithelial Cells / drug effects Epithelial Cells / metabolism Gene Expression Regulation Genome Hydra / drug effects Hydra / genetics Hydra / growth & development Hydra / metabolism* Molecular Sequence Annotation Nitrates / metabolism Nitrogen / metabolism Photosynthesis / genetics RNA, Ribosomal, 18S / genetics RNA, Ribosomal, 18S / metabolism Species Specificity Sugars / pharmacology Symbiosis* / drug effects Symbiosis* / genetics
IF 7.616
Resource
Algae NIES-2166 NIES-2235 NIES-2541