論文 - 詳細
| RRC ID | 53095 |
|---|---|
| 著者 | Hamada M, Schröder K, Bathia J, Kürn U, Fraune S, Khalturina M, Khalturin K, Shinzato C, Satoh N, Bosch TC. |
| タイトル | Metabolic co-dependence drives the evolutionarily ancient Hydra-Chlorella symbiosis. |
| ジャーナル | Elife |
| Abstract |
Many multicellular organisms rely on symbiotic associations for support of metabolic activity, protection, or energy. Understanding the mechanisms involved in controlling such interactions remains a major challenge. In an unbiased approach we identified key players that control the symbiosis between Hydra viridissima and its photosynthetic symbiont Chlorella sp. A99. We discovered significant up-regulation of Hydra genes encoding a phosphate transporter and glutamine synthetase suggesting regulated nutrition supply between host and symbionts. Interestingly, supplementing the medium with glutamine temporarily supports in vitro growth of the otherwise obligate symbiotic Chlorella, indicating loss of autonomy and dependence on the host. Genome sequencing of Chlorella sp. A99 revealed a large number of amino acid transporters and a degenerated nitrate assimilation pathway, presumably as consequence of the adaptation to the host environment. Our observations portray ancient symbiotic interactions as a codependent partnership in which exchange of nutrients appears to be the primary driving force. |
| 巻・号 | 7 |
| 公開日 | 2018-5-31 |
| DOI | 10.7554/eLife.35122 |
| PII | 35122 |
| PMID | 29848439 |
| PMC | PMC6019070 |
| MeSH | Animals Biological Evolution* Chlorella / drug effects Chlorella / genetics Chlorella / metabolism* Conserved Sequence Darkness Epithelial Cells / drug effects Epithelial Cells / metabolism Gene Expression Regulation Genome Hydra / drug effects Hydra / genetics Hydra / growth & development Hydra / metabolism* Molecular Sequence Annotation Nitrates / metabolism Nitrogen / metabolism Photosynthesis / genetics RNA, Ribosomal, 18S / genetics RNA, Ribosomal, 18S / metabolism Species Specificity Sugars / pharmacology Symbiosis* / drug effects Symbiosis* / genetics |
| IF | 7.08 |
| 引用数 | 6 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 30 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 藻類 | NIES-2166 NIES-2235 NIES-2541 |