RRC ID 53166
Author Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A.
Title Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice.
Journal Int Immunol
Abstract Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR.
Volume 30(9)
Pages 429-434
Published 2018-8-30
DOI 10.1093/intimm/dxy025
PII 4946174
PMID 30169732
MeSH Animals Mast Cells / immunology* Mice Mice, Inbred BALB C Mice, Inbred C57BL Pyroglyphidae / immunology* Receptors, Immunologic / immunology* Respiratory Hypersensitivity / immunology* Respiratory Hypersensitivity / pathology
IF 3.519
Times Cited 3
Mice RBRC01888