| RRC ID |
53166
|
| 著者 |
Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A.
|
| タイトル |
Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice.
|
| ジャーナル |
Int Immunol
|
| Abstract |
Although airway hyperresponsiveness (AHR) is a prominent feature of asthma, how it is regulated remains incompletely understood. Allergin-1, an inhibitory immunoglobulin-like receptor containing an immunoreceptor tyrosine-based inhibitory motif (ITIM), is expressed on human and mouse mast cells (MCs) and inhibits high-affinity receptor for IgE (FcεRI)-mediated signaling. Using MC-deficient KitW-sh/W-sh mice and Mas-TRECK mice, which carries a diphtheria toxin (DT)-induced MC deletion system based on il4 enhancer elements, we demonstrate here that MCs are involved in the induction of house dust mite (HDM)-induced AHR. Further, we show that MCs deficient in Allergin-1 exacerbated HDM-induced AHR, but had no effect on airway inflammation. In vitro analysis demonstrated that Allergin-1 inhibited anti-HDM allergen antibody-dependent HDM allergen-mediated degranulation by MCs. Thus, Allergin-1 on MCs plays an important role in the regulation of HDM-induced AHR.
|
| 巻・号 |
30(9)
|
| ページ |
429-434
|
| 公開日 |
2018-8-30
|
| DOI |
10.1093/intimm/dxy025
|
| PII |
4946174
|
| PMID |
30169732
|
| MeSH |
Animals
Mast Cells / immunology*
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Pyroglyphidae / immunology*
Receptors, Immunologic / immunology*
Respiratory Hypersensitivity / immunology*
Respiratory Hypersensitivity / pathology
|
| IF |
3.519
|
| 引用数 |
3
|
| リソース情報 |
| 実験動物マウス |
RBRC01888 |
