論文 - 詳細
| RRC ID | 53182 |
|---|---|
| 著者 | Ohno T, Kai T, Miyasaka Y, Maruyama H, Ishih A, Kino H. |
| タイトル | Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta. |
| ジャーナル | Parasitol Int |
| Abstract |
Hymenolepis diminuta is a parasitic tapeworm of the rat small intestine and is recognized as a useful model for the analysis of cestode-host interactions. In this study, we analyzed factors affecting the biomass of the tapeworm through use of rat strains carrying genetic mutations, namely X-linked severe combined immunodeficiency (xscid; T, B and NK cells deficiency), nude (rnu; T cell deficiency), and mast cell deficient rats. The worm biomass of F344-xscid rats after infection with 5 cysticercoids was much larger than control F344 rats from 3 to 8 weeks. The biomass of F344-rnu rats was also larger than the controls, but was intermediate between F344-xscid and control rats. These observations demonstrated that host immunity can control the maximal tapeworm biomass, i.e., carrying capacity, of the rat small intestine. Both T cell and other immune cells (B and NK cells) have roles in determining the carrying capacity of tapeworms. Total worm biomass and worm numbers in mast cell deficient rats (WsRC-Ws/Ws) were not significantly different from control WsRC-+/+ rats after 3 and 6 weeks of primary infection. Mast cell deficient rats displayed reinfection resistance for worm biomass but not worm expulsion. These findings suggest that the mast cell has a role for controlling the biomass of this tapeworm in reinfection alone, but does not affect the rate of worm expulsion. Overall, our findings indicate that the mast cell is not a major effector cell for the control of the carrying capacity of tapeworms. The identity of the major effector cell remains unknown. |
| 巻・号 | 67(4) |
| ページ | 357-361 |
| 公開日 | 2018-8-1 |
| DOI | 10.1016/j.parint.2018.02.003 |
| PII | S1383-5769(18)30004-7 |
| PMID | 29448016 |
| MeSH | Animals Biomass Host-Parasite Interactions / immunology* Hymenolepiasis / immunology* Hymenolepiasis / parasitology Hymenolepis diminuta / isolation & purification* Hymenolepis diminuta / physiology Intestine, Small / immunology* Intestine, Small / parasitology Mast Cells / immunology Rats Rats, Inbred F344 Rats, Nude T-Lymphocytes / immunology X-Linked Combined Immunodeficiency Diseases |
| IF | 1.866 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ラット | F344-Il2rgem2Kyo (strainID=979) |