| RRC ID |
53182
|
| 著者 |
Ohno T, Kai T, Miyasaka Y, Maruyama H, Ishih A, Kino H.
|
| タイトル |
Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta.
|
| ジャーナル |
Parasitol Int
|
| Abstract |
Hymenolepis diminuta is a parasitic tapeworm of the rat small intestine and is recognized as a useful model for the analysis of cestode-host interactions. In this study, we analyzed factors affecting the biomass of the tapeworm through use of rat strains carrying genetic mutations, namely X-linked severe combined immunodeficiency (xscid; T, B and NK cells deficiency), nude (rnu; T cell deficiency), and mast cell deficient rats. The worm biomass of F344-xscid rats after infection with 5 cysticercoids was much larger than control F344 rats from 3 to 8 weeks. The biomass of F344-rnu rats was also larger than the controls, but was intermediate between F344-xscid and control rats. These observations demonstrated that host immunity can control the maximal tapeworm biomass, i.e., carrying capacity, of the rat small intestine. Both T cell and other immune cells (B and NK cells) have roles in determining the carrying capacity of tapeworms. Total worm biomass and worm numbers in mast cell deficient rats (WsRC-Ws/Ws) were not significantly different from control WsRC-+/+ rats after 3 and 6 weeks of primary infection. Mast cell deficient rats displayed reinfection resistance for worm biomass but not worm expulsion. These findings suggest that the mast cell has a role for controlling the biomass of this tapeworm in reinfection alone, but does not affect the rate of worm expulsion. Overall, our findings indicate that the mast cell is not a major effector cell for the control of the carrying capacity of tapeworms. The identity of the major effector cell remains unknown.
|
| 巻・号 |
67(4)
|
| ページ |
357-361
|
| 公開日 |
2018-8-1
|
| DOI |
10.1016/j.parint.2018.02.003
|
| PII |
S1383-5769(18)30004-7
|
| PMID |
29448016
|
| MeSH |
Animals
Biomass
Host-Parasite Interactions / immunology*
Hymenolepiasis / immunology*
Hymenolepiasis / parasitology
Hymenolepis diminuta / isolation & purification*
Hymenolepis diminuta / physiology
Intestine, Small / immunology*
Intestine, Small / parasitology
Mast Cells / immunology
Rats
Rats, Inbred F344
Rats, Nude
T-Lymphocytes / immunology
X-Linked Combined Immunodeficiency Diseases
|
| IF |
1.866
|
| 引用数 |
1
|
| リソース情報 |
| ラット |
F344-Il2rgem2Kyo (strainID=979) |
