RRC ID |
53259
|
著者 |
Lee YU, Son M, Kim J, Shim YH, Kawasaki I.
|
タイトル |
CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.
|
ジャーナル |
Cell Cycle
|
Abstract |
Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine.
|
巻・号 |
15(5)
|
ページ |
654-66
|
公開日 |
2016-1-1
|
DOI |
10.1080/15384101.2016.1146839
|
PMID |
27104746
|
PMC |
PMC4845952
|
MeSH |
Animals
Caenorhabditis elegans / cytology
Caenorhabditis elegans / embryology*
Caenorhabditis elegans Proteins / physiology*
Cell Division
Cell Nucleus / physiology
Female
Gene Expression
Gene Expression Regulation, Developmental
Intestines / cytology
Intestines / embryology*
Male
Phosphoprotein Phosphatases / physiology*
|
IF |
3.699
|
引用数 |
11
|
リソース情報 |
線虫 |
tm4088 |