論文 - 詳細
| RRC ID | 53259 |
|---|---|
| 著者 | Lee YU, Son M, Kim J, Shim YH, Kawasaki I. |
| タイトル | CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions. |
| ジャーナル | Cell Cycle |
| Abstract |
Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine. |
| 巻・号 | 15(5) |
| ページ | 654-66 |
| 公開日 | 2016-1-1 |
| DOI | 10.1080/15384101.2016.1146839 |
| PMID | 27104746 |
| PMC | PMC4845952 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology* Caenorhabditis elegans Proteins / physiology* Cell Division Cell Nucleus / physiology Female Gene Expression Gene Expression Regulation, Developmental Intestines / cytology Intestines / embryology* Male Phosphoprotein Phosphatases / physiology* |
| IF | 3.699 |
| 引用数 | 11 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm4088 |