RRC ID 53259
Author Lee YU, Son M, Kim J, Shim YH, Kawasaki I.
Title CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.
Journal Cell Cycle
Abstract Intestinal divisions in Caenorhabditis elegans take place in 3 stages: (1) cell divisions during embryogenesis, (2) binucleations at the L1 stage, and (3) endoreduplications at the end of each larval stage. Here, we report that CDC-25.2, a C. elegans ortholog of Cdc25, is required for these specialized division cycles between the 16E cell stage and the onset of endoreduplication. Results of our genetic analyses suggest that CDC-25.2 regulates intestinal cell divisions and binucleations by counteracting WEE-1.3 and by activating the CDK-1/CYB-1 complex. CDC-25.2 activity is then repressed by LIN-23 E3 ubiquitin ligase before the onset of intestinal endoreduplication, and this repression is maintained by LIN-35, the C. elegans ortholog of Retinoblastoma (Rb). These findings indicate that timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine.
Volume 15(5)
Pages 654-66
Published 2016-1-1
DOI 10.1080/15384101.2016.1146839
PMID 27104746
PMC PMC4845952
MeSH Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology* Caenorhabditis elegans Proteins / physiology* Cell Division Cell Nucleus / physiology Female Gene Expression Gene Expression Regulation, Developmental Intestines / cytology Intestines / embryology* Male Phosphoprotein Phosphatases / physiology*
IF 3.259
Times Cited 11
C.elegans tm4088