Reference - Detail
| RRC ID | 53343 |
|---|---|
| Author | Wang D, Hou L, Nakamura S, Su M, Li F, Chen W, Yan Y, Green CD, Chen D, Zhang H, Antebi A, Han JJ. |
| Title | LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis. |
| Journal | Aging Cell |
| Abstract |
The RNA-binding protein LIN-28 was first found to control developmental timing in Caenorhabditis elegans. Later, it was found to play important roles in pluripotency, metabolism, and cancer in mammals. Here we report that a low dosage of lin-28 enhanced stress tolerance and longevity, and reduced germline stem/progenitor cell number in C. elegans. The germline LIN-28-regulated microRNA let-7 was required for these effects by targeting akt-1/2 and decreasing their protein levels. AKT-1/2 and the downstream DAF-16 transcription factor were both required for the lifespan and germline stem cell effects of lin-28. The pathway also mediated dietary restriction induced lifespan extension and reduction in germline stem cell number. Thus, the LIN-28/let-7/AKT/DAF-16 axis we delineated here is a program that plays an important role in balancing reproduction and somatic maintenance and their response to the environmental energy level-a central dogma of the 'evolutionary optimization' of resource allocation that modulates aging. |
| Volume | 16(1) |
| Pages | 113-124 |
| Published | 2017-2-1 |
| DOI | 10.1111/acel.12539 |
| PMID | 27730721 |
| PMC | PMC5242300 |
| MeSH | Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Cell Count Cell Proliferation / radiation effects Gene Knockdown Techniques Germ Cells / cytology* Hot Temperature Longevity / physiology* Longevity / radiation effects Oxidative Stress / radiation effects Signal Transduction* / radiation effects Stem Cells / cytology* Stem Cells / metabolism Stem Cells / radiation effects Stress, Physiological / radiation effects Ultraviolet Rays |
| IF | 7.238 |
| Times Cited | 10 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm4566 |