RRC ID 53408
Author Burton NO, Furuta T, Webster AK, Kaplan RE, Baugh LR, Arur S, Horvitz HR.
Title Insulin-like signalling to the maternal germline controls progeny response to osmotic stress.
Journal Nat Cell Biol
Abstract In 1893 August Weismann proposed that information about the environment could not pass from somatic cells to germ cells, a hypothesis now known as the Weismann barrier. However, recent studies have indicated that parental exposure to environmental stress can modify progeny physiology and that parental stress can contribute to progeny disorders. The mechanisms regulating these phenomena are poorly understood. We report that the nematode Caenorhabditis elegans can protect itself from osmotic stress by entering a state of arrested development and can protect its progeny from osmotic stress by increasing the expression of the glycerol biosynthetic enzyme GPDH-2 in progeny. Both of these protective mechanisms are regulated by insulin-like signalling: insulin-like signalling to the intestine regulates developmental arrest, while insulin-like signalling to the maternal germline regulates glycerol metabolism in progeny. Thus, there is a heritable link between insulin-like signalling to the maternal germline and progeny metabolism and gene expression. We speculate that analogous modulation of insulin-like signalling to the germline is responsible for effects of the maternal environment on human diseases that involve insulin signalling, such as obesity and type-2 diabetes.
Volume 19(3)
Pages 252-257
Published 2017-3-1
DOI 10.1038/ncb3470
PII ncb3470
PMID 28166192
PMC PMC5332277
MeSH Animals Bacterial Infections / pathology Caenorhabditis elegans / microbiology Caenorhabditis elegans / physiology* Germ Cells / metabolism* Insulin / metabolism* Intestines / embryology MAP Kinase Signaling System Osmotic Pressure* Signal Transduction* Starvation Stress, Physiological*
IF 20.042
Times Cited 9
Resource
C.elegans tm1983 tm1922 tm2988 tm6125 tm4467 tm3608 tm2560 tm2416 tm1053 tm2918