論文 - 詳細
| RRC ID | 53410 |
|---|---|
| 著者 | Juozaityte V, Pladevall-Morera D, Podolska A, Nørgaard S, Neumann B, Pocock R. |
| タイトル | The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Animal behavior is shaped through interplay among genes, the environment, and previous experience. As in mammals, satiety signals induce quiescence in Caenorhabditis elegans Here we report that the C. elegans transcription factor ETS-5, an ortholog of mammalian FEV/Pet1, controls satiety-induced quiescence. Nutritional status has a major influence on C. elegans behavior. When foraging, food availability controls behavioral state switching between active (roaming) and sedentary (dwelling) states; however, when provided with high-quality food, C. elegans become sated and enter quiescence. We show that ETS-5 acts to promote roaming and inhibit quiescence by setting the internal "satiety quotient" through fat regulation. Acting from the ASG and BAG sensory neurons, we show that ETS-5 functions in a complex network with serotonergic and neuropeptide signaling pathways to control food-regulated behavioral state switching. Taken together, our results identify a neuronal mechanism for controlling intestinal fat stores and organismal behavioral states in C. elegans, and establish a paradigm for the elucidation of obesity-relevant mechanisms. |
| 巻・号 | 114(9) |
| ページ | E1651-E1658 |
| 公開日 | 2017-2-28 |
| DOI | 10.1073/pnas.1610673114 |
| PII | 1610673114 |
| PMID | 28193866 |
| PMC | PMC5338484 |
| MeSH | Animals Behavior, Animal / physiology* Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Neuropeptides / metabolism Proto-Oncogene Proteins c-ets / metabolism* Sensory Receptor Cells / metabolism Sensory Receptor Cells / physiology Serotonergic Neurons / metabolism Serotonergic Neurons / physiology Signal Transduction / physiology Transcription Factors / metabolism* |
| IF | 9.412 |
| 引用数 | 12 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 51 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1734 tm866 |