論文 - 詳細
| RRC ID | 53431 |
|---|---|
| 著者 | Nelson MD, Janssen T, York N, Lee KH, Schoofs L, Raizen DM. |
| タイトル | FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans. |
| ジャーナル | PLoS One |
| Abstract |
Neuropeptides signal through G-protein coupled receptors (GPCRs) to regulate a broad array of animal behaviors and physiological processes. The Caenorhabditis elegans genome encodes approximately 100 predicted neuropeptide receptor GPCRs, but in vivo roles for only a few have been identified. We describe here a role for the GPCR FRPR-4 in the regulation of behavioral quiescence and locomotive posture. FRPR-4 is activated in cell culture by several neuropeptides with an amidated isoleucine-arginine-phenylalanine (IRF) motif or an amidated valine-arginine-phenylalanine (VRF) motif at their carboxy termini, including those encoded by the gene flp-13. Loss of frpr-4 function results in a minor feeding quiescence defect after heat-induced cellular stress. Overexpression of frpr-4 induces quiescence of locomotion and feeding as well as an exaggerated body bend posture. The exaggerated body bend posture requires the gene flp-13. While frpr-4 is expressed broadly, selective overexpression of frpr-4 in the proprioceptive DVA neurons results in exaggerated body bends that require flp-13 in the ALA neuron. Our results suggest that FLP-13 and other neuropeptides signal through FRPR-4 and other receptors to regulate locomotion posture and behavioral quiescence. |
| 巻・号 | 10(11) |
| ページ | e0142938 |
| 公開日 | 2015-1-1 |
| DOI | 10.1371/journal.pone.0142938 |
| PII | PONE-D-15-36196 |
| PMID | 26571132 |
| PMC | PMC4646455 |
| MeSH | Amino Acid Sequence Animals Behavior, Animal* Caenorhabditis elegans / drug effects Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism* Drosophila melanogaster / metabolism Heat-Shock Response / drug effects Locomotion / drug effects Molecular Sequence Data Neurons / drug effects Neurons / metabolism Peptides / chemistry Peptides / pharmacology Posture Receptors, G-Protein-Coupled / metabolism* Receptors, Neuropeptide / metabolism* |
| IF | 2.74 |
| 引用数 | 7 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | |