RRC ID |
53431
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著者 |
Nelson MD, Janssen T, York N, Lee KH, Schoofs L, Raizen DM.
|
タイトル |
FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans.
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ジャーナル |
PLoS One
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Abstract |
Neuropeptides signal through G-protein coupled receptors (GPCRs) to regulate a broad array of animal behaviors and physiological processes. The Caenorhabditis elegans genome encodes approximately 100 predicted neuropeptide receptor GPCRs, but in vivo roles for only a few have been identified. We describe here a role for the GPCR FRPR-4 in the regulation of behavioral quiescence and locomotive posture. FRPR-4 is activated in cell culture by several neuropeptides with an amidated isoleucine-arginine-phenylalanine (IRF) motif or an amidated valine-arginine-phenylalanine (VRF) motif at their carboxy termini, including those encoded by the gene flp-13. Loss of frpr-4 function results in a minor feeding quiescence defect after heat-induced cellular stress. Overexpression of frpr-4 induces quiescence of locomotion and feeding as well as an exaggerated body bend posture. The exaggerated body bend posture requires the gene flp-13. While frpr-4 is expressed broadly, selective overexpression of frpr-4 in the proprioceptive DVA neurons results in exaggerated body bends that require flp-13 in the ALA neuron. Our results suggest that FLP-13 and other neuropeptides signal through FRPR-4 and other receptors to regulate locomotion posture and behavioral quiescence.
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巻・号 |
10(11)
|
ページ |
e0142938
|
公開日 |
2015-1-1
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DOI |
10.1371/journal.pone.0142938
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PII |
PONE-D-15-36196
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PMID |
26571132
|
PMC |
PMC4646455
|
MeSH |
Amino Acid Sequence
Animals
Behavior, Animal*
Caenorhabditis elegans / drug effects
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism*
Drosophila melanogaster / metabolism
Heat-Shock Response / drug effects
Locomotion / drug effects
Molecular Sequence Data
Neurons / drug effects
Neurons / metabolism
Peptides / chemistry
Peptides / pharmacology
Posture
Receptors, G-Protein-Coupled / metabolism*
Receptors, Neuropeptide / metabolism*
|
IF |
2.74
|
引用数 |
7
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リソース情報 |
線虫 |
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