| RRC ID |
53431
|
| 著者 |
Nelson MD, Janssen T, York N, Lee KH, Schoofs L, Raizen DM.
|
| タイトル |
FRPR-4 Is a G-Protein Coupled Neuropeptide Receptor That Regulates Behavioral Quiescence and Posture in Caenorhabditis elegans.
|
| ジャーナル |
PLoS One
|
| Abstract |
Neuropeptides signal through G-protein coupled receptors (GPCRs) to regulate a broad array of animal behaviors and physiological processes. The Caenorhabditis elegans genome encodes approximately 100 predicted neuropeptide receptor GPCRs, but in vivo roles for only a few have been identified. We describe here a role for the GPCR FRPR-4 in the regulation of behavioral quiescence and locomotive posture. FRPR-4 is activated in cell culture by several neuropeptides with an amidated isoleucine-arginine-phenylalanine (IRF) motif or an amidated valine-arginine-phenylalanine (VRF) motif at their carboxy termini, including those encoded by the gene flp-13. Loss of frpr-4 function results in a minor feeding quiescence defect after heat-induced cellular stress. Overexpression of frpr-4 induces quiescence of locomotion and feeding as well as an exaggerated body bend posture. The exaggerated body bend posture requires the gene flp-13. While frpr-4 is expressed broadly, selective overexpression of frpr-4 in the proprioceptive DVA neurons results in exaggerated body bends that require flp-13 in the ALA neuron. Our results suggest that FLP-13 and other neuropeptides signal through FRPR-4 and other receptors to regulate locomotion posture and behavioral quiescence.
|
| 巻・号 |
10(11)
|
| ページ |
e0142938
|
| 公開日 |
2015-1-1
|
| DOI |
10.1371/journal.pone.0142938
|
| PII |
PONE-D-15-36196
|
| PMID |
26571132
|
| PMC |
PMC4646455
|
| MeSH |
Amino Acid Sequence
Animals
Behavior, Animal*
Caenorhabditis elegans / drug effects
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism*
Drosophila melanogaster / metabolism
Heat-Shock Response / drug effects
Locomotion / drug effects
Molecular Sequence Data
Neurons / drug effects
Neurons / metabolism
Peptides / chemistry
Peptides / pharmacology
Posture
Receptors, G-Protein-Coupled / metabolism*
Receptors, Neuropeptide / metabolism*
|
| IF |
2.74
|
| 引用数 |
7
|
| リソース情報 |
| 線虫 |
|
