RRC ID 53446
Author Stein KK, Golden A.
Title The C. elegans eggshell.
Journal WormBook
Abstract In all animals, oocytes are surrounded by an extracellular matrix upon fertilization. This matrix serves similar purposes in each animal. It functions to mediate sperm binding, to prevent polyspermy, to control the chemical environment of the embryo, and to provide physical protection to the embryo as it developes. The synthesis of the C. elegans matrix, or eggshell, begins when the oocyte enters the spermatheca and is fertilized by a single sperm. The process of eggshell synthesis is thought to take place during the completion of the maternal meiotic divisions such that the multi-layered eggshell is completed by anaphase II. The synthesis of the eggshell occurs in a hierarchical pattern in which the outermost layers are synthesized first in order to capture and retain the innermost layers as they form. Recent studies have revealed that the lipid-rich permeability barrier is distinct from the outer trilaminar eggshell. These new findings alter our previous understanding of the eggshell. This chapter aims to define each of the eggshell layers and the molecules that are known to play significant roles in their formation.
Volume 2018
Pages 1-36
Published 2018-8-2
DOI 10.1895/wormbook.1.179.1
PMID 26715360
PMC PMC5603424
MeSH Animals Caenorhabditis elegans / anatomy & histology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / biosynthesis Caenorhabditis elegans Proteins / physiology Extracellular Matrix Proteins / biosynthesis Extracellular Matrix Proteins / physiology* Female Oocytes / cytology Oocytes / physiology*
C.elegans tm5197 tm2711 tm3224 tm4368 tm2068 tm3575 tm947 tm5187 tm2257 tm3828 tm1942 tm4868 tm2743 tm2225 tm4637 tm1457 tm3158 tm3267 tm4705