Reference - Detail
| RRC ID | 53464 |
|---|---|
| Author | Reddy KC, Dunbar TL, Nargund AM, Haynes CM, Troemel ER. |
| Title | The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity. |
| Journal | Cell Rep |
| Abstract |
Pathogens attack host cells by deploying toxins that perturb core host processes. Recent findings from the nematode C. elegans and other metazoans indicate that surveillance or "effector-triggered" pathways monitor functioning of these core processes and mount protective responses when they are perturbed. Despite a growing number of examples of surveillance immunity, the signaling components remain poorly defined. Here, we show that CEBP-2, the C. elegans ortholog of mammalian CCAAT-enhancer-binding protein gamma, is a key player in surveillance immunity. We show that CEBP-2 acts together with the bZIP transcription factor ZIP-2 in the protective response to translational block by P. aeruginosa Exotoxin A as well as perturbations of other processes. CEBP-2 serves to limit pathogen burden, promote survival upon P. aeruginosa infection, and also promote survival upon Exotoxin A exposure. These findings may have broad implications for the mechanisms by which animals sense pathogenic attack and mount protective responses. |
| Volume | 14(7) |
| Pages | 1581-1589 |
| Published | 2016-2-23 |
| DOI | 10.1016/j.celrep.2016.01.055 |
| PII | S2211-1247(16)30033-X |
| PMID | 26876169 |
| PMC | PMC4767654 |
| MeSH | ADP Ribose Transferases / biosynthesis ADP Ribose Transferases / immunology Animals Bacterial Toxins / biosynthesis Bacterial Toxins / immunology CCAAT-Enhancer-Binding Proteins / antagonists & inhibitors CCAAT-Enhancer-Binding Proteins / genetics CCAAT-Enhancer-Binding Proteins / immunology* Caenorhabditis elegans / genetics Caenorhabditis elegans / immunology* Caenorhabditis elegans / microbiology Caenorhabditis elegans Proteins / antagonists & inhibitors Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / immunology* Death-Associated Protein Kinases / antagonists & inhibitors Death-Associated Protein Kinases / genetics Death-Associated Protein Kinases / immunology* Exotoxins / biosynthesis Exotoxins / immunology Gene Expression Regulation / immunology Host-Pathogen Interactions* Immunity, Innate Immunologic Surveillance* Pseudomonas aeruginosa / growth & development* Pseudomonas aeruginosa / immunology RNA, Small Interfering / genetics RNA, Small Interfering / metabolism Signal Transduction Survival Rate Virulence Factors / biosynthesis Virulence Factors / immunology |
| IF | 8.109 |
| Times Cited | 15 |
| Resource | |
| C.elegans | tm5421 tm4248 |