論文 - 詳細
| RRC ID | 53472 |
|---|---|
| 著者 | Nagashima T, Oami E, Kutsuna N, Ishiura S, Suo S. |
| タイトル | Dopamine regulates body size in Caenorhabditis elegans. |
| ジャーナル | Dev Biol |
| Abstract |
The nervous system plays a critical role in the regulation of animal body sizes. In Caenorhabditis elegans, an amine neurotransmitter, dopamine, is required for the tactile perception of food and food-dependent behavioral changes, while its role in development is unknown. In this study, we show that dopamine negatively regulates body size through a D2-like dopamine receptor, DOP-3, in C. elegans. Dopamine alters body size without affecting food intake or developmental rate. We also found that dopamine promotes egg-laying, although the regulation of body size by dopamine was not solely caused by this effect. Furthermore, dopamine negatively regulates body size through the suppression of signaling by octopamine and Gq-coupled octopamine receptors, SER-3 and SER-6. Our results demonstrate that dopamine and octopamine regulate the body size of C. elegans and suggest a potential role for perception in addition to ingestion of food for growth. |
| 巻・号 | 412(1) |
| ページ | 128-138 |
| 公開日 | 2016-4-1 |
| DOI | 10.1016/j.ydbio.2016.02.021 |
| PII | S0012-1606(16)30100-2 |
| PMID | 26921458 |
| MeSH | Animals Body Size* Caenorhabditis elegans / anatomy & histology* Caenorhabditis elegans / physiology Dopamine / physiology* Transforming Growth Factor beta / metabolism |
| IF | 2.896 |
| 引用数 | 8 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2261 tm2735 tm2146 tm3890 |