RRC ID 53613
Author Yamamoto K, Nakano M, Ishihama A.
Title Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli.
Journal Microbiology (Reading)
Abstract Sulfur makes up 1 % of the dry mass of bacteria, and it is an abundant element (0.1 %) on earth. Sulfur in the environment is, however, mostly in oxidized forms and inaccessible to living organisms. At present, the entire assimilation pathway of external sulfur to sulfur-containing biomolecules and its regulation in Escherichia coli remain poorly understood, except for the metabolic pathway of cysteine synthesis, the first-step metabolite of sulfur assembly. During the search for regulation targets of uncharacterized transcription factors by Genomic SELEX screening, we found that the hitherto uncharacterized YdcN regulates a set of genes involved in the utilization of sulfur, including the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. Taking these findings together, we propose renaming YdcN as SutR (regulator of sulfur utilization).
Volume 161(Pt 1)
Pages 99-111
Published 2015-1-1
DOI 10.1099/mic.0.083550-0
PMID 25406449
MeSH Base Sequence Binding Sites DNA, Intergenic Escherichia coli / genetics* Escherichia coli / metabolism* Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism* Gene Expression Regulation, Bacterial* Gene Order Gene Regulatory Networks Genomics Molecular Sequence Data Promoter Regions, Genetic Reproducibility of Results SELEX Aptamer Technique Sulfur / metabolism* Transcription Factors / metabolism* Transcription Initiation Site Transcription, Genetic
IF 2.138
Prokaryotes E. coli