論文 - 詳細
| RRC ID | 53653 |
|---|---|
| 著者 | Yamamoto K, Nakano M, Ishihama A. |
| タイトル | Regulatory role of transcription factor SutR (YdcN) in sulfur utilization in Escherichia coli. |
| ジャーナル | Microbiology (Reading) |
| Abstract |
Sulfur makes up 1 % of the dry mass of bacteria, and it is an abundant element (0.1 %) on earth. Sulfur in the environment is, however, mostly in oxidized forms and inaccessible to living organisms. At present, the entire assimilation pathway of external sulfur to sulfur-containing biomolecules and its regulation in Escherichia coli remain poorly understood, except for the metabolic pathway of cysteine synthesis, the first-step metabolite of sulfur assembly. During the search for regulation targets of uncharacterized transcription factors by Genomic SELEX screening, we found that the hitherto uncharacterized YdcN regulates a set of genes involved in the utilization of sulfur, including the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. Taking these findings together, we propose renaming YdcN as SutR (regulator of sulfur utilization). |
| 巻・号 | 161(Pt 1) |
| ページ | 99-111 |
| 公開日 | 2015-1-1 |
| DOI | 10.1099/mic.0.083550-0 |
| PMID | 25406449 |
| MeSH | Base Sequence Binding Sites DNA, Intergenic Escherichia coli / genetics* Escherichia coli / metabolism* Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism* Gene Expression Regulation, Bacterial* Gene Order Gene Regulatory Networks Genomics Molecular Sequence Data Promoter Regions, Genetic Reproducibility of Results SELEX Aptamer Technique Sulfur / metabolism* Transcription Factors / metabolism* Transcription Initiation Site Transcription, Genetic |
| IF | 2.138 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 原核生物(大腸菌) | |