論文 - 詳細
| RRC ID | 53664 |
|---|---|
| 著者 | Jiafeng L, Fu X, Chang Z. |
| タイトル | Hypoionic shock treatment enables aminoglycosides antibiotics to eradicate bacterial persisters. |
| ジャーナル | Sci Rep |
| Abstract |
Bacterial persisters, usually being considered as dormant cells that are tolerant to antibiotics, are an important source for recurrent infection and emergence of antibiotic resistant pathogens. Clinical eradication of pathogenic persisters is highly desired but greatly difficult mainly due to the substantial reduction in antibiotics uptake as well as the non-active state of the drug targets. Here we report that bacterial persisters (normal growing cells as well) can be effectively eradicated by aminoglycoside antibiotics upon hypoionic shock (e.g. pure water treatment) even for less than one minute. Such hypoionic shock potentiation effect on aminoglycosides is proton motive force-independent, and is apparently achieved by promoting the entrance of aminoglycosides, speculatively through the mechanosensitive ion channels. Our revelations may provide a simple and powerful strategy to eradicate pathogen persisters. |
| 巻・号 | 5 |
| ページ | 14247 |
| 公開日 | 2015-10-5 |
| DOI | 10.1038/srep14247 |
| PII | srep14247 |
| PMID | 26435063 |
| PMC | PMC4593029 |
| MeSH | Aminoglycosides / pharmacology* Anti-Bacterial Agents / pharmacology* Drug Resistance, Bacterial Microbial Sensitivity Tests Osmotic Pressure Proton-Motive Force Staphylococcus aureus / drug effects Staphylococcus aureus / physiology |
| IF | 3.998 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | |