論文 - 詳細
| RRC ID | 53787 |
|---|---|
| 著者 | Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R. |
| タイトル | High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice. |
| ジャーナル | Nat Microbiol |
| Abstract |
Immunoglobulin A (IgA) is the main antibody isotype secreted into the intestinal lumen. IgA plays a critical role in the defence against pathogens and in the maintenance of intestinal homeostasis. However, how secreted IgA regulates gut microbiota is not completely understood. In this study, we isolated monoclonal IgA antibodies from the small intestine of healthy mouse. As a candidate for an efficient gut microbiota modulator, we selected a W27 IgA, which binds to multiple bacteria, but not beneficial ones such as Lactobacillus casei. W27 could suppress the cell growth of Escherichia coli but not L. casei in vitro, indicating an ability to improve the intestinal environment. Indeed W27 oral treatment could modulate gut microbiota composition and have a therapeutic effect on both lymphoproliferative disease and colitis models in mice. Thus, W27 IgA oral treatment is a potential remedy for inflammatory bowel disease, acting through restoration of host-microbial symbiosis. |
| 巻・号 | 1(9) |
| ページ | 16103 |
| 公開日 | 2016-7-4 |
| DOI | 10.1038/nmicrobiol.2016.103 |
| PII | nmicrobiol2016103 |
| PMID | 27562257 |
| MeSH | Animals Antibodies, Monoclonal Colitis / immunology Colitis / microbiology Colitis / prevention & control* Escherichia coli / growth & development Escherichia coli / immunology Female Gastrointestinal Microbiome / immunology* Homeostasis Immunoglobulin A, Secretory / immunology* Inflammatory Bowel Diseases / immunology Inflammatory Bowel Diseases / microbiology Inflammatory Bowel Diseases / prevention & control* Intestine, Small / immunology Intestine, Small / microbiology Intestines / immunology Intestines / microbiology Male Mice Mice, Inbred BALB C Symbiosis |
| IF | 15.54 |
| 引用数 | 44 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 70 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 原核生物(大腸菌) | ME9062 JW2535 |