| RRC ID |
53833
|
| 著者 |
Jing W, Qin F, Guo X, Sun Y, Yan C, Qiu C, Tanaka M, Shi B, Zhao Y.
|
| タイトル |
G-CSF mediates lung injury in mice with adenine-induced acute kidney injury.
|
| ジャーナル |
Int Immunopharmacol
|
| Abstract |
Acute lung injury (ALI) is a serious complication among patients with acute kidney injury (AKI) that is a systemic inflammatory disease with high morbidity and mortality. The pathophysiology of AKI-associated ALI is poorly understood. G-CSF regulates the production and function of neutrophils that mediate lung injury via elastase and other mediators. Here, we used a mouse model of adenine-induced AKI to determine the roles of G-CSF and neutrophil elastase in AKI-associated ALI. We confirmed that ALI was associated with high serum G-CSF levels, and elevated neutrophil elastase activity in the lungs and serum of mice with adenine-induced AKI. Systemic administration of G-CSF-specific neutralizing antibody normalized granulopoiesis, pulmonary neutrophil infiltration, and neutrophil elastase activity, conferring improved lung architecture in mice with adenine-induced AKI. Further studies revealed that macrophages secreted G-CSF upon urea stimulation. Consequently, G-CSF could be a target for new anti-lung injury strategy in patients with AKI.
|
| 巻・号 |
63
|
| ページ |
1-8
|
| 公開日 |
2018-10-1
|
| DOI |
10.1016/j.intimp.2018.07.032
|
| PII |
S1567-5769(18)30361-8
|
| PMID |
30056257
|
| MeSH |
Acute Kidney Injury / chemically induced
Acute Kidney Injury / complications
Acute Kidney Injury / immunology*
Acute Lung Injury / etiology
Acute Lung Injury / immunology*
Adenine
Animals
Bronchoalveolar Lavage Fluid / immunology
Female
Granulocyte Colony-Stimulating Factor / immunology*
Leukocyte Elastase / immunology
Macrophages, Peritoneal / immunology
Mice, Inbred C57BL
Urea / pharmacology
|
| IF |
3.943
|
| 引用数 |
2
|
| リソース情報 |
| 実験動物マウス |
RBRC04395 |
