論文 - 詳細
| RRC ID | 53833 |
|---|---|
| 著者 | Jing W, Qin F, Guo X, Sun Y, Yan C, Qiu C, Tanaka M, Shi B, Zhao Y. |
| タイトル | G-CSF mediates lung injury in mice with adenine-induced acute kidney injury. |
| ジャーナル | Int Immunopharmacol |
| Abstract |
Acute lung injury (ALI) is a serious complication among patients with acute kidney injury (AKI) that is a systemic inflammatory disease with high morbidity and mortality. The pathophysiology of AKI-associated ALI is poorly understood. G-CSF regulates the production and function of neutrophils that mediate lung injury via elastase and other mediators. Here, we used a mouse model of adenine-induced AKI to determine the roles of G-CSF and neutrophil elastase in AKI-associated ALI. We confirmed that ALI was associated with high serum G-CSF levels, and elevated neutrophil elastase activity in the lungs and serum of mice with adenine-induced AKI. Systemic administration of G-CSF-specific neutralizing antibody normalized granulopoiesis, pulmonary neutrophil infiltration, and neutrophil elastase activity, conferring improved lung architecture in mice with adenine-induced AKI. Further studies revealed that macrophages secreted G-CSF upon urea stimulation. Consequently, G-CSF could be a target for new anti-lung injury strategy in patients with AKI. |
| 巻・号 | 63 |
| ページ | 1-8 |
| 公開日 | 2018-10-1 |
| DOI | 10.1016/j.intimp.2018.07.032 |
| PII | S1567-5769(18)30361-8 |
| PMID | 30056257 |
| MeSH | Acute Kidney Injury / chemically induced Acute Kidney Injury / complications Acute Kidney Injury / immunology* Acute Lung Injury / etiology Acute Lung Injury / immunology* Adenine Animals Bronchoalveolar Lavage Fluid / immunology Female Granulocyte Colony-Stimulating Factor / immunology* Leukocyte Elastase / immunology Macrophages, Peritoneal / immunology Mice, Inbred C57BL Urea / pharmacology |
| IF | 3.943 |
| 引用数 | 2 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 実験動物マウス | RBRC04395 |