論文 - 詳細
| RRC ID | 53871 |
|---|---|
| 著者 | Hiratsuka S, Tomita T, Mishima T, Matsunaga Y, Omori T, Ishibashi S, Yamaguchi S, Hosogane T, Watarai H, Omori-Miyake M, Yamamoto T, Shibata N, Watanabe A, Aburatani H, Tomura M, High KA, Maru Y. |
| タイトル | Hepato-entrained B220+CD11c+NK1.1+ cells regulate pre-metastatic niche formation in the lung. |
| ジャーナル | EMBO Mol Med |
| Abstract |
Primary tumours establish metastases by interfering with distinct organs. In pre-metastatic organs, a tumour-friendly microenvironment supports metastatic cells and is prepared by many factors including tissue resident cells, bone marrow-derived cells and abundant fibrinogen depositions. However, other components are unclear. Here, we show that a third organ, originally regarded as a bystander, plays an important role in metastasis by directly affecting the pre-metastatic soil. In our model system, the liver participated in lung metastasis as a leucocyte supplier. These liver-derived leucocytes displayed liver-like characteristics and, thus, were designated hepato-entrained leucocytes (HepELs). HepELs had high expression levels of coagulation factor X (FX) and vitronectin (Vtn) and relocated to fibrinogen-rich hyperpermeable regions in pre-metastatic lungs; the cells then switched their expression from Vtn to thrombospondin, both of which were fibrinogen-binding proteins. Cell surface marker analysis revealed that HepELs contained B220+CD11c+NK1.1+ cells. In addition, an injection of B220+CD11c+NK1.1+ cells successfully eliminated fibrinogen depositions in pre-metastatic lungs via FX Moreover, B220+CD11c+NK1.1+ cells demonstrated anti-metastatic tumour ability with IFNγ induction. These findings indicate that liver-primed B220+CD11c+NK1.1+ cells suppress lung metastasis. |
| 巻・号 | 10(7) |
| 公開日 | 2018-7-1 |
| DOI | 10.15252/emmm.201708643 |
| PII | emmm.201708643 |
| PMID | 29930175 |
| PMC | PMC6034134 |
| MeSH | Animals CD11 Antigens Female Fibrinogen / metabolism Flow Cytometry Humans Interferon-gamma / immunology Killer Cells, Natural / immunology* Leukocyte Common Antigens Liver / immunology Liver / pathology* Lung / immunology Lung / pathology* Lung Neoplasms / immunology Lung Neoplasms / pathology* Lung Neoplasms / secondary Male Mice Neoplasm Metastasis* Precancerous Conditions* |
| IF | 8.821 |
| 引用数 | 1 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00267 |