RRC ID 53875
Author Tseng CY, Su YH, Yang SM, Lin KY, Lai CM, Rastegari E, Amartuvshin O, Cho Y, Cai Y, Hsu HJ.
Title Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool.
Journal Stem Cell Reports
Abstract In developing organisms, proper tuning of the number of stem cells within a niche is critical for the maintenance of adult tissues; however, the involved mechanisms remain largely unclear. Here, we demonstrate that Thickveins (Tkv), a type I bone morphogenetic protein (BMP) receptor, acts in the Drosophila developing ovarian soma through a Smad-independent pathway to shape the distribution of BMP signal within the niche, impacting germline stem cell (GSC) recruitment and maintenance. Somatic Tkv promotes Egfr signaling to silence transcription of Dally, which localizes BMP signals on the cell surface. In parallel, Tkv promotes Hh signaling, which promotes escort cell cellular protrusions and upregulates expression of the Drosophila BMP homolog, Dpp, forming a positive feedback loop that enhances Tkv signaling and strengthens the niche boundary. Our results reveal a role for non-canonical BMP signaling in the soma during GSC establishment and generally illustrate how complex, cell-specific BMP signaling mediates niche-stem cell interactions.
Volume 11(3)
Pages 811-827
Published 2018-9-11
DOI 10.1016/j.stemcr.2018.07.008
PII S2213-6711(18)30313-8
PMID 30122445
PMC PMC6135924
MeSH Animals Bone Morphogenetic Proteins / metabolism* Cell Differentiation Drosophila / cytology Drosophila / growth & development Drosophila / metabolism* Drosophila Proteins / metabolism* Female Germ Cells / cytology* Germ Cells / metabolism Male Ovary / cytology Ovary / growth & development Ovary / metabolism Protein Serine-Threonine Kinases / metabolism* Receptors, Cell Surface / metabolism* Signal Transduction* Smad Proteins / metabolism* Stem Cell Niche
IF 6.032
Times Cited 7
Resource
Drosophila 14026R-3 4637R-2 4974R-1 9885R-2 2411R-1