Reference - Detail
| RRC ID | 53925 |
|---|---|
| Author | Ameku T, Yoshinari Y, Texada MJ, Kondo S, Amezawa K, Yoshizaki G, Shimada-Niwa Y, Niwa R. |
| Title | Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner. |
| Journal | PLoS Biol |
| Abstract |
Stem cell maintenance is established by neighboring niche cells that promote stem cell self-renewal. However, it is poorly understood how stem cell activity is regulated by systemic, tissue-extrinsic signals in response to environmental cues and changes in physiological status. Here, we show that neuropeptide F (NPF) signaling plays an important role in the pathway regulating mating-induced germline stem cell (GSC) proliferation in the fruit fly Drosophila melanogaster. NPF expressed in enteroendocrine cells (EECs) of the midgut is released in response to the seminal-fluid protein sex peptide (SP) upon mating. This midgut-derived NPF controls mating-induced GSC proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs. Our study provides a molecular mechanism that describes how a gut-derived systemic factor couples stem cell behavior to physiological status, such as mating, through interorgan communication. |
| Volume | 16(9) |
| Pages | e2005004 |
| Published | 2018-9-1 |
| DOI | 10.1371/journal.pbio.2005004 |
| PII | pbio.2005004 |
| PMID | 30248087 |
| PMC | PMC6152996 |
| MeSH | Animals Base Sequence Bone Morphogenetic Proteins / metabolism Cell Count Cell Division Cell Proliferation Digestive System / metabolism* Drosophila Proteins / metabolism* Drosophila melanogaster / metabolism* Ecdysteroids / metabolism Enteroendocrine Cells / metabolism Female Germ Cells / cytology* Germ Cells / metabolism Models, Biological Neuropeptides / metabolism* Ovary / metabolism Receptors, Neuropeptide / metabolism Sexual Behavior, Animal Signal Transduction Stem Cells / cytology* Stem Cells / metabolism* |
| IF | 7.076 |
| Times Cited | 13 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 59 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | |