Reference - Detail
| RRC ID | 53935 |
|---|---|
| Author | Kinashi T, Harada N, Severinson E, Tanabe T, Sideras P, Konishi M, Azuma C, Tominaga A, Bergstedt-Lindqvist S, Takahashi M. |
| Title | Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II. |
| Journal | Nature |
| Abstract |
Proliferation and maturation of antigen-stimulated B cells are regulated by several soluble factors derived from macrophages and T cells. These soluble factors are functionally divided into two groups: B-cell growth factor (BCGF), thought to be involved in B-cell proliferation; and B-cell differentiation factor (BCDF), responsible for maturation of activated B cells into immunoglobulin-secreting cells. This classification needs to be re-examined in the light of the recent cloning of complementary DNA encoding IgG1 induction factor (interleukin-4, IL-4) from the 2.19 mouse T-cell line. Recombinant IL-4 has BCGF and BCDF activities and affects B cells, T cells and mast cells (refs 7, 8; our unpublished data). Another well-characterized B-cell factor is T-cell replacing factor (TRF), which, when secreted by the murine T-cell hybridoma B151K12, is defined by two activities: induction of IgM secretion by BCL1 leukaemic B-cell line; and induction of secondary anti-dinitrophenol (DNP) immunoglobulin G (IgG) synthesis in vitro by DNP-prime B cells. Although TRF from B151K12 was classified as BCDF, purified TRF has BCGF-II activity. To elucidate the molecular properties of TRF we isolated cDNA encoding TRF from the 2.19 T-cell line and report here the structure and multiple activities of this lymphokine. |
| Volume | 324(6092) |
| Pages | 70-3 |
| Published | 1986-11-6 |
| DOI | 10.1038/324070a0 |
| PMID | 3024009 |
| MeSH | Animals Base Sequence Cloning, Molecular DNA / metabolism DNA Restriction Enzymes / metabolism Growth Substances / metabolism* Interleukin-4 Interleukin-5 Lymphokines / genetics Lymphokines / metabolism* Mice |
| IF | 42.779 |
| Times Cited | 440 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 12 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | pSP6K. m . TRF23 (RDB01174) |