論文 - 詳細
| RRC ID | 53984 |
|---|---|
| 著者 | Chiba M, Kubota S, Sato K, Monzen S. |
| タイトル | Exosomes released from pancreatic cancer cells enhance angiogenic activities via dynamin-dependent endocytosis in endothelial cells in vitro. |
| ジャーナル | Sci Rep |
| Abstract |
Pancreatic cancer has the lowest 5 year survival rate among all cancers. Several extracellular factors are involved in the development and metastasis of pancreatic cancer to distant organs. Exosomes are lipid-bilayer, membrane-enclosed nanoparticles that are recognised as important mediators of cell-to-cell communications. However, the role of exosomes released from pancreatic cancer cells in tumour micro-environment remains unknown. Here, we show that exosomes released from pancreatic cancer PK-45H cells activate various gene expressions in human umbilical vein endothelial cells (HUVECs) by in vitro analyses. In addition, these exosomes released from PK-45H cells promote phosphorylation of Akt and ERK1/2 signalling pathway molecules and tube formation via dynamin-dependent endocytosis in HUVECs. Our findings suggested that exosomes released from pancreatic cancer cells may act as a novel angiogenesis promoter. |
| 巻・号 | 8(1) |
| ページ | 11972 |
| 公開日 | 2018-8-10 |
| DOI | 10.1038/s41598-018-30446-1 |
| PII | 10.1038/s41598-018-30446-1 |
| PMID | 30097593 |
| PMC | PMC6086824 |
| MeSH | Biomarkers Cell Proliferation Dynamins / metabolism* Endocytosis* Exosomes / metabolism* Human Umbilical Vein Endothelial Cells / metabolism* Humans Neovascularization, Pathologic / metabolism* Pancreatic Neoplasms / metabolism* Pancreatic Neoplasms / pathology* Signal Transduction Tumor Microenvironment |
| IF | 3.998 |
| 引用数 | 16 |
| リソース情報 | |
| ヒト・動物細胞 | PK-45H(RCB1973) |